Laï J L, Fenaux P, Pollet J P, Estienne M H, Savary J B, Huart J J, Deminatti M
Service de Génétique, Faculté de Médecine, Lille, France.
Cancer Genet Cytogenet. 1988 Jul 1;33(1):99-109. doi: 10.1016/0165-4608(88)90055-6.
Childhood acute lymphocytic leukemia (ALL) with partial deletion of the short arm of chromosome 9 (9p-), particularly in the p21-22 region, associated with bulky disease, has been regarded as a possible subgroup of ALL. We have reviewed clinical and cytologic data in 128 cases of ALL (childhood and adult). Four of them had 9p anomalies. Two patients had a deletion in the 9p21 region associated with another deletion (9p13----pter) in one case and with t(1;19)(q21;p13) in the second patient. A third patient had a t(9;14)(p21;q12) balanced translocation associated with 14q22----qter deletion; the last patient showed a t(5;9)(p14;q21) unbalanced translocation also associated with 14q deletion. All four patients had lymphomatous ALL, but immunophenotype was non-T, in the four cases, (non-T, non-B in two patients and common ALL in the two remaining cases). Acute lymphocytic leukemia with 9p anomalies appears relatively frequently and is usually associated with poor prognostic features (i.e., bulk disease and high leukocyte counts) but does not seem restricted to childhood and T-cell lineage.
伴有9号染色体短臂部分缺失（9p-），尤其是p21-22区域缺失且与巨大肿块性疾病相关的儿童急性淋巴细胞白血病（ALL），被认为是ALL的一个可能亚组。我们回顾了128例ALL（儿童和成人）的临床和细胞学资料。其中4例存在9p异常。2例患者在9p21区域有缺失，1例与另一个缺失（9p13----pter）相关，另1例与t(1;19)(q21;p13)相关。第3例患者有t(9;14)(p21;q12)平衡易位并伴有14q22----qter缺失；最后1例患者表现为t(5;9)(p14;q21)不平衡易位，也伴有14q缺失。所有4例患者均为淋巴瘤性ALL，但4例的免疫表型均为非T细胞型（2例为非T、非B细胞型，另2例为普通ALL型）。伴有9p异常的急性淋巴细胞白血病相对常见，通常与不良预后特征（如巨大肿块性疾病和高白细胞计数）相关，但似乎不限于儿童和T细胞系。
