Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-8-31 Midorioka, Ikeda, Osaka, 563-8577, Japan.
Core Research for Evolutional Science and Technology (CREST), Kawaguchi, 332-0012, Japan.
Cell Tissue Res. 2020 Oct;382(1):125-134. doi: 10.1007/s00441-020-03274-x. Epub 2020 Sep 8.
Brain-derived neurotrophic factor (BDNF) is known to control a wide variety of brain functions, ranging from memory formation to food intake. However, since the BDNF levels are extremely low in the nervous system, the dynamics in neurons from intracellular trafficking to secretion is absolutely complicated; the understanding is not fully promoted. We here review the findings of those critical mechanisms from intracellular trafficking to the secretion of BDNF. Furthermore, to solve this issue, technological advances for the detection, measurement, and imaging of this growth factor are essential. We believe that this review helps the study of these complex but critical mechanisms of BDNF.
脑源性神经营养因子（BDNF）已知可控制从记忆形成到食物摄入等各种大脑功能。然而，由于神经系统中的 BDNF 水平极低，因此从细胞内运输到分泌的神经元动力学极其复杂；理解尚未完全促进。我们在此回顾了从 BDNF 的细胞内运输到分泌的这些关键机制的发现。此外，为了解决这个问题，检测、测量和成像这种生长因子的技术进步至关重要。我们相信，这篇综述有助于研究 BDNF 的这些复杂但关键的机制。
