Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Clinical Oral Research Laboratory, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Acta Odontol Scand. 2021 Apr;79(3):205-211. doi: 10.1080/00016357.2020.1817546. Epub 2020 Sep 8.
The aims of the present study were to evaluate the relative incidence of alveolar osteitis (AO) after mandibular third molar surgery, post-operative findings and local expression of bone markers and cytokines.
In 445 patients, unilateral surgical third molars extractions were undertaken (584 teeth). Bone markers and cytokines were explored at the AO side and on the un-operated contralateral side and compared with the levels in samples from a control group of 18 persons without AO.
The relative incidence of AO was 4.6%. Patients ( = 27) with AO were invited to participate in the study and 21 (77.8%) did so. Patients with AO had 1-4 extra visits for treatment of AO, the mean follow-up time was 2.6 days for all patients. There were significantly higher levels of bone markers and cytokines in the AO site compared with the un-operated contralateral site, except for Epidermal growth factor (EGF). No significant difference in expression of bone markers and cytokines between the AO and control groups was found. Lower maximum inter-incisor opening (MIO) was correlated with increased Macrophage inflammatory protein 1 alpha. A negative correlation between patients' complaint of trismus and MIO was seen.
The relative incidence of AO was low in our patient group treated with surgical removal of third molars. AO was more frequently seen in female patients. Treatment of AO required up to four extra visits. The study provides some information on the role of cytokines in AO; but further studies are required.
本研究旨在评估下颌第三磨牙手术后发生牙槽骨炎（AO）的相对发病率、术后发现以及骨标志物和细胞因子的局部表达。
在 445 名患者中，进行了单侧下颌第三磨牙手术拔牙（584 颗牙齿）。在 AO 侧和未手术的对侧侧探索骨标志物和细胞因子，并与来自无 AO 的对照组 18 人的样本水平进行比较。
AO 的相对发病率为 4.6%。邀请患有 AO 的患者（ = 27）参加研究，其中 21 名（77.8%）患者参加。患有 AO 的患者接受了 1-4 次额外的 AO 治疗访问，所有患者的平均随访时间为 2.6 天。与未手术的对侧部位相比，AO 部位的骨标志物和细胞因子水平明显更高，除表皮生长因子（EGF）外。在 AO 组和对照组之间，骨标志物和细胞因子的表达没有显著差异。最大切牙开口（MIO）越低，巨噬细胞炎症蛋白 1 阿尔法增加。患者对张口受限的抱怨与 MIO 呈负相关。
我们的研究中，接受外科拔牙治疗的下颌第三磨牙患者中，AO 的相对发病率较低。女性患者中更常见 AO。治疗 AO 需要多达 4 次额外的就诊。该研究提供了一些关于细胞因子在 AO 中作用的信息；但需要进一步的研究。
