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[胆囊癌的外科治疗]

[Surgical therapy of gallbladder cancer].

作者信息

Köckerling F, Scheele J, Gall F P

机构信息

Chirurgische Klinik mit Poliklinik, Universität Erlangen-Nürnberg.

出版信息

Chirurg. 1988 Apr;59(4):236-43.

PMID:3289848
Abstract

Because of the normally far advanced tumor stages of carcinomas of the gallbladder, the resection rate in the literature varies from 10 to 30 percent. Our own curative resection rate was 19% in a series of 89 patients between 1969 and 1985 first treated in our hospital. The palliative resection rate was 29%, in 10% we performed a palliative operation and in 36% an explorative laparotomy. The curative resected gallbladder carcinomas were mainly stage I and II tumors, incidentally found at operation or histopathological examination. Has the gallbladder carcinoma invaded perimuscular connective tissue, an extended operation with resection of the segments IVb and V of the liver and lymphnode dissection must be recommended. Stage III and IV carcinomas of the gallbladder with infiltration of the liver can be curatively operated organ-saving in using en-bloc resection of the gallbladder with the adjacent segments IVb and V, or IVb and VI and with lymphnode dissection of the hepatoduodenal ligament. The observed five-year-survival rate (Cutler and Ederer) including lethality of the curative resected carcinoma of the gallbladder is 56.3 +/- 25.2%.

摘要

由于胆囊癌通常处于较晚期的肿瘤阶段,文献中的切除率在10%至30%之间。在1969年至1985年期间,我院首次治疗的89例患者中,我们自己的根治性切除率为19%。姑息性切除率为29%,其中10%的患者接受了姑息性手术,36%的患者接受了剖腹探查术。根治性切除的胆囊癌主要为I期和II期肿瘤,多在手术或组织病理学检查时偶然发现。如果胆囊癌侵犯了肌周结缔组织,则建议进行扩大手术,切除肝IVb段和V段并进行淋巴结清扫。对于侵犯肝脏的III期和IV期胆囊癌,可通过将胆囊与相邻的IVb段和V段或IVb段和VI段整块切除,并对肝十二指肠韧带进行淋巴结清扫,从而进行根治性的保器官手术。观察到的包括根治性切除的胆囊癌致死率在内的五年生存率(卡特勒和埃德勒法)为56.3±25.2%。

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