Zhang Chun-Yang, Yang Bin, Li Dong-Mei, Shi Qiu-Yan, Li Hong, Li Yan-Ling, Wang Cui-Lan
Medicine (Baltimore). 2020 Sep 4;99(36):e21958. doi: 10.1097/MD.0000000000021958.
Wake up stroke starts in sleep and is a more common form of ischemic stroke. At present, it is still controversial whether wake up stroke can be treated with thrombolytic therapy. Therefore, this study will combine imaging techniques to assess the onset time of wake up stroke patients, and to analyze the imaging characteristics of wake up stroke patients and patients suitable for thrombolytic therapy within the time window.
METHODS/DESIGN: This study will be a single-blinded, randomized controlled trial with 2 parallel groups. It will be conducted at North China University of science and technology affiliated hospital.
There is no consistent conclusion about the pathogenesis of wake up stroke. Wake up stroke is more likely to manifest as small vessel disease. The incidence of wake up stroke patients is relatively high, and the effectiveness and safety of intravenous thrombolysis under the guidance of multimode imaging therapy in wake up stroke need to be further explored by prospective, large-scale studies.
ClinicalTrials.gov, ChiCTR2000034402, Registered on 05 July 2020.
醒后卒中始于睡眠，是缺血性卒中的一种较常见形式。目前，醒后卒中是否可用溶栓治疗仍存在争议。因此，本研究将结合影像学技术评估醒后卒中患者的发病时间，并分析醒后卒中患者及在时间窗内适合溶栓治疗患者的影像学特征。
方法/设计：本研究将是一项单盲、随机对照试验，分为2个平行组。研究将在华北理工大学附属医院进行。
关于醒后卒中的发病机制尚无一致结论。醒后卒中更易表现为小血管病。醒后卒中患者的发病率相对较高，多模态影像指导下静脉溶栓治疗醒后卒中的有效性和安全性有待前瞻性、大规模研究进一步探索。
ClinicalTrials.gov，ChiCTR2000034402，于2020年7月5日注册。
