Programa de Pós-Graduação em Genética e Biologia Molecular, Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), RS, Brazil.
Programa de Pós-Graduação em Biologia Celular e Molecular, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), RS, Brazil.
Plant Sci. 2020 Oct;299:110603. doi: 10.1016/j.plantsci.2020.110603. Epub 2020 Jul 24.
Programmed cell death (PCD) is a genetically controlled process that leads to cell suicide in both eukaryotic and prokaryotic organisms. In plants PCD occurs during development, defence response and when exposed to adverse conditions. PCD acts controlling the number of cells by eliminating damaged, old, or unnecessary cells to maintain cellular homeostasis. Unlike in animals, the knowledge about PCD in plants is limited. The molecular network that controls plant PCD is poorly understood. Here we present a review of the current mechanisms involved with the genetic control of PCD in plants. We also present an updated version of the AtLSD1 deathosome, which was previously proposed as a network controlling HR-mediated cell death in Arabidopsis thaliana. Finally, we discuss the unclear points and open questions related to the AtLSD1 deathosome.
程序性细胞死亡 (PCD) 是一种受基因控制的过程，导致真核生物和原核生物的细胞自杀。在植物中，PCD 发生在发育、防御反应和暴露于不利条件时。PCD 通过消除受损、衰老或不必要的细胞来控制细胞数量，以维持细胞内稳态。与动物不同，植物中 PCD 的知识有限。控制植物 PCD 的分子网络还知之甚少。在这里，我们回顾了目前涉及植物 PCD 的遗传控制的机制。我们还呈现了先前提出的作为拟南芥 HR 介导细胞死亡的网络的 AtLSD1 死亡体的更新版本。最后，我们讨论了与 AtLSD1 死亡体相关的不清楚的问题和未解决的问题。
