Department of Burns and Cutaneous Surgery, The First Affiliated Hospital, Air Force Medical University, Xi'an 710032, China.
Department of Nursing, The First Affiliated Hospital, Air Force Medical University, Xi'an 710032, China.
Burns. 2021 May;47(3):628-633. doi: 10.1016/j.burns.2020.07.026. Epub 2020 Aug 11.
Burn injury leads to mitochondrial dysfunction and autophagy, also known as mitophagy. The alleviation of mitochondrial damage may be a potential method for the treatment of burn injury and complications. In this animal study, we analyzed the expression of mitochondrial damage- and mitophagy-related factors, specifically PINK1 and PRKN. The results showed mitochondria damage in the skin; compared with the normal control group, genes involved in the mitochondrial damage, such as Nrf-1, UQCRC2, CYC1, and NDUFA9, as well as in the mitophagy, including PINK1, PRKN, MFN1, and USP30, were differentially expressed. Furthermore, PINK1 interacted with PRKN and participated in mitophagy in the skin. In conclusion, our data reveal more about the mechanism underlying mitophagy in burns, providing a potential clinical treatment.
烧伤导致线粒体功能障碍和自噬，也称为线粒体自噬。缓解线粒体损伤可能是治疗烧伤及并发症的一种潜在方法。在这项动物研究中，我们分析了与线粒体损伤和线粒体自噬相关的因子（PINK1 和 PRKN）的表达。结果显示皮肤中的线粒体损伤；与正常对照组相比，线粒体损伤相关的基因，如 Nrf-1、UQCRC2、CYC1 和 NDUFA9，以及线粒体自噬相关的基因，如 PINK1、PRKN、MFN1 和 USP30，均有差异表达。此外，PINK1 与 PRKN 相互作用，并参与皮肤中的线粒体自噬。总之，我们的数据揭示了烧伤中线粒体自噬的更多潜在临床治疗机制。
