Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Department of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
J Hum Genet. 2021 Feb;66(2):219-223. doi: 10.1038/s10038-020-00837-2. Epub 2020 Sep 8.
Type 2 diabetes mellitus (T2DM) and rheumatoid arthritis (RA) are both chronic diseases. Although the link between metabolic abnormalities and dysregulated inflammation has received much attention, it is not known whether T2DM can be a risk for the development of RA. Also, observational studies have the disadvantage that the possibility of confounding factors, such as environmental factors, cannot be ruled out. Therefore, the current study performed the mendelian randomization (MR) analysis using recent large-scale genome-wide association studies datasets of T2DM and RA separately European and Asian ancestries. As a result, T2DM had an inverse causal effect on the risk of RA. This study proposed a novel hypothesis that a protective effect of T2DM for the risk of RA.
2 型糖尿病（T2DM）和类风湿关节炎（RA）都是慢性病。尽管代谢异常和炎症失调之间的联系受到了广泛关注，但 T2DM 是否会增加 RA 的发病风险尚不清楚。此外，观察性研究的缺点是不能排除环境等混杂因素的可能性。因此，本研究利用 T2DM 和 RA 的全基因组关联研究数据集，分别在欧洲和亚洲人群中进行了孟德尔随机化（MR）分析。结果表明，T2DM 对 RA 的发病风险有反向因果效应。该研究提出了一个新的假设，即 T2DM 对 RA 的发病风险具有保护作用。
