Varlibas Figen, Akhan Ozkan, Can Murat, Yuksel Gulbun, Gul Zeynep B
Clin Lab. 2020 Sep 1;66(9). doi: 10.7754/Clin.Lab.2020.200516.
Human serum paraoxonase1 (PON1) is a high-density lipoprotein (HDL) associated antioxidant enzymes. We aimed to research the PON1 activity in Alzheimer's disease (AD) not accompanied with any disorders and other conditions influencing the PON1 activity.
We studied the PON1 activity and PON1 related lipid parameters in two groups, probable sporadic late onset AD (n:30) and those with healthy subjects (n:32). These groups were homogeneous, in which the subjects did not have any cardiovascular risk factors or other conditions affecting PON1 activity.
We found increased high-density lipoprotein cholesterol (HDL-C) and significantly decreased PON1 activity in the AD patients. A patient with a PON1 activity value of ≤ 151 U/L had a 5.48-fold higher risk for AD, compared to those with a PON1 activity value of > 151 U/L.
Decreased PON1 activity may play a role in the oxidative stress (OS) related pathogenesis of AD. An increased HDL-C with the decreased PON1 activity may bring the concept of dysfunctional HDL into question in the pathogenesis of AD. It may be emphasized in the pathogenesis of AD for further studies.
人血清对氧磷酶1（PON1）是一种与高密度脂蛋白（HDL）相关的抗氧化酶。我们旨在研究未伴有任何疾病及其他影响PON1活性状况的阿尔茨海默病（AD）患者的PON1活性。
我们研究了两组对象的PON1活性及与PON1相关的血脂参数，其中一组为可能的散发性晚发型AD患者（n = 30），另一组为健康受试者（n = 32）。这两组对象具有同质性，均不存在任何心血管危险因素或其他影响PON1活性的状况。
我们发现AD患者的高密度脂蛋白胆固醇（HDL-C）升高，而PON1活性显著降低。与PON1活性值> 151 U/L的患者相比，PON1活性值≤ 151 U/L的患者患AD的风险高5.48倍。
PON1活性降低可能在AD的氧化应激（OS）相关发病机制中起作用。HDL-C升高而PON1活性降低可能使功能失调的HDL这一概念在AD发病机制中受到质疑。在AD发病机制方面可能需要进一步研究加以强调。
