J Opt Soc Am A Opt Image Sci Vis. 2020 Sep 1;37(9):1398-1403. doi: 10.1364/JOSAA.395387.
The paper describes the results of finite-difference time-domain (FDTD) mathematical modeling of electromagnetic fields distortion near the surfaces of core-shell gold-based spherical gold nanoparticles (NPs). NPs were consistently functionalized by two shells of different thickness: a water shell, as a model substance for a drug, and an shell, as a capsuling layer. The calculated field values were converted into the electromagnetic field enhancement coefficient and the surface-enhanced Raman scattering (SERS) intensity. Prospects of the theoretical approach for core-shell NPs modeling to evaluate optimal field amplification and light-scattering parameters have been shown. The presented approach could be applied as a basis for performing methods of controlled synthesis for colloidal core-shell theranostic NPs.
本文描述了基于金核壳球形金纳米粒子（NPs）表面的电磁场失真的有限差分时域（FDTD）数学建模的结果。NPs 被两个不同厚度的壳层一致地功能化：水壳作为药物模型物质，和壳作为胶囊层。计算出的场值被转换为电磁场增强系数和表面增强拉曼散射（SERS）强度。已经显示了该理论方法在核壳 NPs 建模中评估最佳场放大和光散射参数的应用前景。所提出的方法可作为进行胶体核壳治疗性 NPs 可控合成方法的基础。
