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1
Histological lesions associated with cyclosporin: incidence and reversibility in one year old kidney transplants.与环孢素相关的组织学病变：一岁肾移植受者中的发生率及可逆性
J Clin Pathol. 1988 May;41(5):498-503. doi: 10.1136/jcp.41.5.498.
2
Morphological differentiation between rejection and cyclosporin nephrotoxicity in renal allografts.同种异体肾移植中排斥反应与环孢素肾毒性的形态学鉴别
J Clin Pathol. 1986 Feb;39(2):152-9. doi: 10.1136/jcp.39.2.152.
3
Cyclosporin and renal graft histology.环孢素与肾移植组织学
J Clin Pathol. 1986 Feb;39(2):145-51. doi: 10.1136/jcp.39.2.145.
4
Renal histopathology in kidney transplant recipients immunosuppressed with cyclosporin A: results of an international workshop.
Clin Nephrol. 1985 Sep;24(3):107-19.
5
Differentiation between allograft rejection and cyclosporin nephrotoxicity in renal-transplant recipients.
Lancet. 1985 Jul 27;2(8448):171-4. doi: 10.1016/s0140-6736(85)91495-3.
6
'Nephrotoxicity' and metabolic acidosis in transplant patients on cyclosporin A.接受环孢素A治疗的移植患者中的“肾毒性”和代谢性酸中毒。
Proc Eur Dial Transplant Assoc. 1981;18:400-9.
7
[Biopsy findings in kidney transplants after treatment with cyclosporin A].[环孢素A治疗后肾移植的活检结果]
Zentralbl Allg Pathol. 1986;132(5-6):423-33.
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Interstitial fibrosis in renal allografts after 12 to 46 months of cyclosporin treatment: beneficial effect of low doses in early post-transplantation period.
Lancet. 1984 Oct 27;2(8409):950-4. doi: 10.1016/s0140-6736(84)91166-8.
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[The diagnosis of cyclosporin nephrotoxicity in patients after kidney transplantation].
Ter Arkh. 1990;62(6):92-4.
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Kidney pathology in liver allograft recipients after long-term treatment with cyclosporin A.
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Protective Effect of Edaravone Against Cyclosporine-Induced Chronic Nephropathy Through Antioxidant and Nitric Oxide Modulating Pathways in Rats.依达拉奉通过抗氧化和一氧化氮调节途径对环孢素诱导的大鼠慢性肾病的保护作用
Iran J Med Sci. 2017 Mar;42(2):170-178.
2
Cyclosporine-induced nephrotoxicity in deoxycorticosterone-NaCl treated rats.环孢素对脱氧皮质酮-氯化钠处理大鼠的肾毒性作用
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本文引用的文献

1
Cyclosporine-induced nephrotoxicity. Inevitable and intractable?
N Engl J Med. 1984 Sep 13;311(11):728-9. doi: 10.1056/NEJM198409133111109.
2
Characteristics of early routine renal allograft biopsies.早期常规肾移植活检的特征
Transplantation. 1984 Dec;38(6):679-84. doi: 10.1097/00007890-198412000-00026.
3
Acute cellular rejection or Cyclosporine A nephrotoxicity? A review of transplant renal biopsies.
Am J Kidney Dis. 1984 Sep;4(2):185-91. doi: 10.1016/s0272-6386(84)80070-0.
4
Renal biopsy morphology in renal transplantation. A comparative study of the light-microscopic appearances of biopsies from patients treated with cyclosporin A or azathioprine prednisone and antilymphocyte globulin.
Am J Surg Pathol. 1984 Apr;8(4):243-52.
5
Cyclosporine nephrotoxicity.环孢素肾毒性。
Ann Intern Med. 1983 Dec;99(6):851-4. doi: 10.7326/0003-4819-99-6-851.
6
Morphology of cyclosporine nephrotoxicity and acute rejection in patients immunosuppressed with cyclosporine and prednisone.接受环孢素和泼尼松免疫抑制治疗的患者中环孢素肾毒性和急性排斥反应的形态学
Surgery. 1983 Aug;94(2):225-34.
7
Interstitial fibrosis in renal allografts after 12 to 46 months of cyclosporin treatment: beneficial effect of low doses in early post-transplantation period.
Lancet. 1984 Oct 27;2(8409):950-4. doi: 10.1016/s0140-6736(84)91166-8.
8
The effect of long-term cyclosporin A on renal function.长期使用环孢素A对肾功能的影响。
Lancet. 1981 May 30;1(8231):1218-9. doi: 10.1016/s0140-6736(81)92392-8.
9
A high carbohydrate leguminous fibre diet improves all aspects of diabetic control.高碳水化合物豆类纤维饮食可改善糖尿病控制的各个方面。
Lancet. 1981 Jan 3;1(8210):1-5. doi: 10.1016/s0140-6736(81)90112-4.
10
Renal histopathology in kidney transplant recipients immunosuppressed with cyclosporin A: results of an international workshop.
Clin Nephrol. 1985 Sep;24(3):107-19.

与环孢素相关的组织学病变：一岁肾移植受者中的发生率及可逆性

Histological lesions associated with cyclosporin: incidence and reversibility in one year old kidney transplants.

作者信息

Versluis D J, Ten Kate F J, Wenting G J, Jeekel J, Weimar W

机构信息

Department of Internal Medicine, University Hospital, Rotterdam-Dijkzigt, The Netherlands.

出版信息

J Clin Pathol. 1988 May;41(5):498-503. doi: 10.1136/jcp.41.5.498.

DOI:10.1136/jcp.41.5.498
PMID:3290264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1141500/
Abstract

To determine the type and reversibility of the long term effects of cyclosporin A, biopsy specimens were taken from 20 recipients of kidney allografts, twelve months after transplantation, and three months later, during which time azathioprine was substituted for cyclosporin A. Arteriolar IgM and complement deposits and tubular isometric vacuolisation associated with cyclosporin A treatment significantly regressed after stopping this drug one year after transplantation. Conversion to azathioprine was accompanied by an increase in mononuclear cell infiltrates and tubulitis despite an evident improvement in renal function. Nephrotoxicity as a result of cyclosporin A is common but can be reversed--at least partially.

摘要

为了确定环孢素A长期影响的类型和可逆性，在移植12个月后从20例肾移植受者身上获取活检标本，3个月后，在此期间用硫唑嘌呤替代环孢素A。与环孢素A治疗相关的小动脉IgM和补体沉积以及肾小管等距空泡化在移植后1年停用该药后显著消退。尽管肾功能明显改善，但转换为硫唑嘌呤后单核细胞浸润和肾小管炎增加。环孢素A导致的肾毒性很常见，但至少可以部分逆转。