Department of Obstetrics and Gynecology, School of Medicine, Pamukkale University, 20070, Denizli, Turkey.
Department of Histology and Embryology, School of Medicine, Pamukkale University, Denizli, Turkey.
Arch Gynecol Obstet. 2021 Jan;303(1):269-278. doi: 10.1007/s00404-020-05783-0. Epub 2020 Sep 9.
To evaluate the effect of the ejaculatory abstinence period on sperm DNA fragmentation and pregnancy rates in IUI cycles.
One hundred and twenty couples with unexplained infertility were prospectively randomized into two groups on the second day of their cycle. In group A, patients had 1-day ejaculatory abstinence period; in group B patients had 3-day ejaculatory abstinence period. Each patient was stimulated with gonadotropins, and IUI was performed. The primary outcome measure was clinical pregnancy and sperm DNA fragmentation rate.
The pregnancy rate was 17.3% and 18.5% in group A and group B, respectively. No significant difference was found among the groups (p = 0.803). The sperm DNA fragmentation rate for group A (20.71 ± 11.01) and group B (23.78 ± 12.64) were almost similar (p = 0.187). The sperm DNA fragmentation rate was 24.89 ± 12.89 in pregnant couples and 21.71 ± 11.69 in non-pregnant couples (p = 0.288).
Even after a short abstinence period of 1 day, compared to the standard abstinence period of 3 days, pregnancy rates are similar among unexplained infertility couples undergoing ovarian stimulation and IUI.
The study was registered at ClinicalTrials.gov with ID NCT04361292. Date of registration: 27 April 2020. The study was registered retrospectively.
评估射精禁欲期对 IUI 周期中精子 DNA 碎片化和妊娠率的影响。
120 对不明原因不孕的夫妇在周期的第二天前瞻性随机分为两组。在 A 组中，患者有 1 天的射精禁欲期；在 B 组中，患者有 3 天的射精禁欲期。每位患者均接受促性腺激素刺激，并进行 IUI。主要结局指标为临床妊娠率和精子 DNA 碎片化率。
A 组和 B 组的妊娠率分别为 17.3%和 18.5%。两组间无显著差异（p=0.803）。A 组（20.71±11.01）和 B 组（23.78±12.64）的精子 DNA 碎片化率几乎相似（p=0.187）。妊娠组的精子 DNA 碎片化率为 24.89±12.89，非妊娠组的精子 DNA 碎片化率为 21.71±11.69（p=0.288）。
与标准的 3 天禁欲期相比，在接受卵巢刺激和 IUI 的不明原因不孕夫妇中，即使是短暂的 1 天禁欲期，妊娠率也相似。
该研究在 ClinicalTrials.gov 上注册，编号为 NCT04361292。注册日期：2020 年 4 月 27 日。该研究是回顾性注册的。
