College of Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
College of Nursing, Department of Biobehavioral Health Science (M/C 802), University of Illinois at Chicago, 845 S Damen Avenue, Chicago, IL, 60612, USA.
Aging Clin Exp Res. 2021 Jul;33(7):1885-1894. doi: 10.1007/s40520-020-01695-w. Epub 2020 Sep 9.
Cognitive impairment is a common complication of aging that is also associated with chronic kidney disease (CKD). Vascular dysfunction has been implicated as a potential cause of cognitive impairment in older adults, with particular deficits noted in those with CKD.
To determine the differences in cognitive function and vascular compliance in older adults with and without CKD with preclinical cognitive impairment and the relationship between these factors.
Utilizing a cross-sectional approach, 48 older adults with preclinical cognitive impairment (24 with and 24 without CKD) were evaluated for performance on a test of global cognition and executive function, and vascular compliance via tonometry and ultrasound.
Cognitive function and some indicators of vascular function were significantly different in older adults with and without CKD. Global cognition was correlated with carotid-femoral pulse wave velocity (r = - 0.36, p = 0.02) in the entire sample. Vascular function was not correlated with executive function.
Older adults with preclinical cognitive impairment and CKD had different cognitive and vascular function than those without CKD, and an indicator of vascular function may have a relationship with cognitive function in older adults.
The findings of this study support the assessment of cognitive and vascular function in older adults with and without CKD with preclinical cognitive impairment.
认知障碍是衰老的常见并发症，也与慢性肾脏病（CKD）有关。血管功能障碍被认为是老年人认知障碍的潜在原因，在 CKD 患者中尤其存在缺陷。
确定伴有和不伴有 CKD 的认知障碍前期老年人的认知功能和血管顺应性的差异，以及这些因素之间的关系。
采用横断面研究方法，评估 48 例认知障碍前期老年人（24 例伴有 CKD，24 例不伴有 CKD）的整体认知和执行功能测试表现，以及通过张力测定法和超声评估血管顺应性。
伴有和不伴有 CKD 的老年人的认知功能和一些血管功能指标存在显著差异。在整个样本中，整体认知与颈股脉搏波速度呈负相关（r=-0.36，p=0.02）。血管功能与执行功能无关。
伴有认知障碍前期和 CKD 的老年人的认知和血管功能与不伴有 CKD 的老年人不同，血管功能的一个指标可能与老年人的认知功能有关。
本研究的结果支持对伴有和不伴有认知障碍前期 CKD 的老年人进行认知和血管功能评估。
