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III期非小细胞肺癌根治性放化疗后局部复发行挽救性立体定向放射治疗后的长期生存病例

A long-term survival case following salvage stereotactic radiotherapy for local recurrence after definitive chemoradiotherapy for stage III non-small cell lung cancer.

作者信息

Sato Yuta, Jingu Keiichi, Umezawa Rei, Yamamoto Takaya, Ishikawa Yojiro, Takeda Kazuya, Suzuki Yu, Matsushita Haruo

机构信息

Department of Radiation Oncology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-chou, Aoba-ku, Sendai, 980-8574 Japan.

出版信息

Int Cancer Conf J. 2020 Jul 3;9(4):227-230. doi: 10.1007/s13691-020-00431-5. eCollection 2020 Oct.

Abstract

A 56-year-old male with stage IIIA (UICC 7th) non-small cell lung cancer (adenocarcinoma) received radiotherapy with 66 Gy/33 fractions concomitant with CBDCA and PTX. A partial response was achieved after chemoradiotherapy and the tumor continued to shrink over a period of 1 year; however, regrowth of the tumor attached to the aortic arch was observed without any other residual tumor or metastases. We diagnosed recurrence with slightly increased F-FDG uptake (maximum standardized uptake value: 12.2). Stereotactic radiotherapy was performed for the relapsed lesion with 60 Gy/10 fractions. The patient has survived for more than 5 years after stereotactic radiotherapy without recurrence or metastases, although he has been suffering from chest pain that has required treatment with a low dose of oxycodone.

摘要

一名56岁男性,患有IIIA期(国际抗癌联盟第7版)非小细胞肺癌(腺癌),接受了66 Gy/33次分割的放疗,同时使用卡铂(CBDCA)和紫杉醇(PTX)。放化疗后取得部分缓解,肿瘤在1年时间内持续缩小;然而,观察到附着于主动脉弓的肿瘤复发,无任何其他残留肿瘤或转移灶。我们诊断为复发,氟代脱氧葡萄糖(F-FDG)摄取略有增加(最大标准化摄取值:12.2)。对复发灶进行了60 Gy/10次分割的立体定向放疗。立体定向放疗后,患者已存活超过5年,无复发或转移,尽管他一直遭受胸痛,需要用低剂量羟考酮治疗。

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