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Avelumab for patients with previously treated metastatic or recurrent non-small-cell lung cancer (JAVELIN Solid Tumor): dose-expansion cohort of a multicentre, open-label, phase 1b trial.阿维鲁单抗用于既往接受过治疗的转移性或复发性非小细胞肺癌患者(JAVELIN实体瘤研究):一项多中心、开放标签的1b期试验的剂量扩展队列研究
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Prospective Trial of Stereotactic Body Radiation Therapy for Both Operable and Inoperable T1N0M0 Non-Small Cell Lung Cancer: Japan Clinical Oncology Group Study JCOG0403.立体定向体部放疗治疗可手术和不可手术 T1N0M0 期非小细胞肺癌的前瞻性研究:日本临床肿瘤学组研究 JCOG0403。
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Stereotactic body radiation therapy (SBRT) for lung cancer patients previously treated with conventional radiotherapy: a review.立体定向体部放射治疗用于曾接受传统放疗的肺癌患者:一项综述
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Patterns of locoregional failure in stage III non-small cell lung cancer treated with definitive chemoradiation therapy.接受根治性放化疗的Ⅲ期非小细胞肺癌的局部区域复发模式
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Stereotactic body radiation therapy for re-irradiation of persistent or recurrent non-small cell lung cancer.立体定向体部放疗用于复发性或持续性非小细胞肺癌的再照射。
Int J Radiat Oncol Biol Phys. 2014 Apr 1;88(5):1114-9. doi: 10.1016/j.ijrobp.2014.01.012.
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Outcomes of stereotactic ablative radiotherapy for central lung tumours: a systematic review.立体定向消融放疗治疗中央型肺部肿瘤的疗效:系统评价。
Radiother Oncol. 2013 Mar;106(3):276-82. doi: 10.1016/j.radonc.2013.01.004. Epub 2013 Feb 22.
7
Prognostic factors for local control of stage I non-small cell lung cancer in stereotactic radiotherapy: a retrospective analysis.立体定向放疗治疗 I 期非小细胞肺癌局部控制的预后因素:回顾性分析。
Radiat Oncol. 2012 Oct 31;7:182. doi: 10.1186/1748-717X-7-182.
8
A phase II study on stereotactic body radiotherapy for stage I non-small cell lung cancer.一项关于立体定向体部放疗治疗 I 期非小细胞肺癌的 II 期研究。
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Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study.I期非小细胞肺癌的大分割立体定向放射治疗(HypoFXSRT):日本多机构研究中257例患者的更新结果
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III期非小细胞肺癌根治性放化疗后局部复发行挽救性立体定向放射治疗后的长期生存病例

A long-term survival case following salvage stereotactic radiotherapy for local recurrence after definitive chemoradiotherapy for stage III non-small cell lung cancer.

作者信息

Sato Yuta, Jingu Keiichi, Umezawa Rei, Yamamoto Takaya, Ishikawa Yojiro, Takeda Kazuya, Suzuki Yu, Matsushita Haruo

机构信息

Department of Radiation Oncology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-chou, Aoba-ku, Sendai, 980-8574 Japan.

出版信息

Int Cancer Conf J. 2020 Jul 3;9(4):227-230. doi: 10.1007/s13691-020-00431-5. eCollection 2020 Oct.

DOI:10.1007/s13691-020-00431-5
PMID:32904079
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7450021/
Abstract

A 56-year-old male with stage IIIA (UICC 7th) non-small cell lung cancer (adenocarcinoma) received radiotherapy with 66 Gy/33 fractions concomitant with CBDCA and PTX. A partial response was achieved after chemoradiotherapy and the tumor continued to shrink over a period of 1 year; however, regrowth of the tumor attached to the aortic arch was observed without any other residual tumor or metastases. We diagnosed recurrence with slightly increased F-FDG uptake (maximum standardized uptake value: 12.2). Stereotactic radiotherapy was performed for the relapsed lesion with 60 Gy/10 fractions. The patient has survived for more than 5 years after stereotactic radiotherapy without recurrence or metastases, although he has been suffering from chest pain that has required treatment with a low dose of oxycodone.

摘要

一名56岁男性,患有IIIA期(国际抗癌联盟第7版)非小细胞肺癌(腺癌),接受了66 Gy/33次分割的放疗,同时使用卡铂(CBDCA)和紫杉醇(PTX)。放化疗后取得部分缓解,肿瘤在1年时间内持续缩小;然而,观察到附着于主动脉弓的肿瘤复发,无任何其他残留肿瘤或转移灶。我们诊断为复发,氟代脱氧葡萄糖(F-FDG)摄取略有增加(最大标准化摄取值:12.2)。对复发灶进行了60 Gy/10次分割的立体定向放疗。立体定向放疗后,患者已存活超过5年,无复发或转移,尽管他一直遭受胸痛,需要用低剂量羟考酮治疗。