二甲双胍对非糖尿病大鼠钛铝钒合金种植体周围骨填充率的影响。
The effects of metformin on the bone filling ration around of TiAlVa implants in non diabetic rats.
作者信息
Yıldırım Tuba Talo, Dündar Serkan, Bozoğlan Alihan, Karaman Tahir, Kahraman Onur Evren, Özcan Erhan Cahit
机构信息
Department of Periodontology, Faculty of Dentistry, Firat University, Elazig, Turkey.
Department of Prosthodontics, Faculty of Dentistry, Firat University, Elazig, Turkey.
出版信息
J Oral Biol Craniofac Res. 2020 Oct-Dec;10(4):474-477. doi: 10.1016/j.jobcr.2020.07.012. Epub 2020 Aug 8.
OBJECTIVES
In this research it was aimed to that evaluation of the effects of systemic metformin administration on the periimplant bone tissue response of TiAlVa implants in experimental rat model.
MATERIALS AND METHOD
Firstly TiAlVa implants were inserted surgically in the metaphyseal part of the tibial bone and after, the rats were randomly separated into two groups: Controls (CNT) (n = 10) and Metformin group (M) (n = 10). No additional treatment was applied to the controls during the 4-week experimental period. Rats received 40 mg/kg metformin in every day during the four week experimental period in M group. At the end of the 28-day follow-up period, the TiAlVa implants with surrounding bone were used for the histopathologic analysis. To analysis of the datas between M and CNT Student-T Test was used.
RESULT
Periimplant bone tissue filling ratios (%) were detected higher in M group compared with the CNT (P < 0.05).
CONCLUSION
Systemic administration of metformin may increases titanium implant osseointegration in non-diabetic rats.
目的
本研究旨在评估在实验大鼠模型中，全身性给予二甲双胍对TiAlVa种植体周围骨组织反应的影响。
材料与方法
首先将TiAlVa种植体通过手术植入胫骨的干骺端部分，之后将大鼠随机分为两组：对照组（CNT）（n = 10）和二甲双胍组（M）（n = 10）。在为期4周的实验期间，对照组未接受额外治疗。在4周的实验期间，M组大鼠每天接受40mg/kg二甲双胍。在28天的随访期结束时，将带有周围骨组织的TiAlVa种植体用于组织病理学分析。使用Student-T检验分析M组和CNT组之间的数据。
结果
检测发现，M组的种植体周围骨组织填充率（%）高于CNT组（P < 0.05）。
结论
在非糖尿病大鼠中，全身性给予二甲双胍可能会增加钛种植体的骨整合。
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