Mauriello S M, Bader J D
Department of Dental Ecology, School of Dentistry, University of North Carolina, Chapel Hill 27514.
J Periodontol. 1988 Apr;59(4):238-43. doi: 10.1902/jop.1988.59.4.238.
A six-month, double-blind clinical trial was conducted to determine the effectiveness of a sanguinarine-containing dentifrice in reducing plaque and gingival inflammation. One hundred twenty adult volunteers were randomly assigned to a control or experimental group. The test dentifrice contained 750 mcg/g of sanguinaria extract. A dentifrice of similar composition without sanguinarine was used as the placebo. Plaque and gingival inflammation scores were recorded for four surfaces on each of 12 index teeth at baseline, one-, three, and six-months. Matched pair t-test analyses showed no significant differences between experimental and control groups for mean six-month changes in plaque and gingival inflammation scores in analyses using all 48 sites per subject or in analyses of only the 24 interproximal sites. No long-term reduction was demonstrated in plaque or gingival inflammation with the use of a sanguinarine-containing dentifrice.
进行了一项为期六个月的双盲临床试验，以确定含血根碱的牙膏在减少牙菌斑和牙龈炎症方面的有效性。120名成年志愿者被随机分配到对照组或实验组。测试牙膏含有750微克/克的血根草提取物。使用不含血根碱的类似成分牙膏作为安慰剂。在基线、1个月、3个月和6个月时，记录12颗指数牙每颗牙四个面的牙菌斑和牙龈炎症评分。配对t检验分析表明，在使用每位受试者所有48个部位进行分析或仅分析24个邻面部位时，实验组和对照组在六个月的牙菌斑和牙龈炎症评分平均变化方面没有显著差异。使用含血根碱的牙膏未显示出牙菌斑或牙龈炎症的长期减少。
