Cultivation Base of State Key Laboratory for Ecological Restoration and Ecosystem Management of Jilin Province and Ministry of Science and Technology, College of Chinese Medicinal Materials, Jilin Agricultural University, 130118, Changchun, Jilin, China.
Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China.
Neural Plast. 2020 Aug 21;2020:8814531. doi: 10.1155/2020/8814531. eCollection 2020.
Mesaconitine (MA), a diester-diterpenoid alkaloid in aconite roots, is considered to be one of the most important bioactive ingredients. In this review, we summarized its neuropharmacological effects, including analgesic effects and antiepileptiform effects. Mesaconitine can act on the central noradrenergic system and the serotonin system; behaving like the norepinephrine reuptake inhibitors and tricyclic antidepressants that increase norepinephrine levels in stress-induced depression. Therefore, the possible perspectives for future studies on the depression of MA were also discussed as well. The pharmacological effect of MA on depression is worthy of further study.
乌头碱（MA）是附子根中的一种二酯二萜生物碱，被认为是最重要的生物活性成分之一。在这篇综述中，我们总结了其神经药理学作用，包括镇痛作用和抗癫痫作用。乌头碱可以作用于中枢去甲肾上腺素能系统和 5-羟色胺系统；表现得像去甲肾上腺素再摄取抑制剂和三环类抗抑郁药一样，增加应激诱导性抑郁中去甲肾上腺素的水平。因此，还讨论了 MA 治疗抑郁症的未来研究的可能前景。MA 对抑郁症的药理作用值得进一步研究。
