乌头碱类生物碱中乌头碱和苯甲酰中乌头碱的镇痛机制。
Antinociceptive mechanism of the aconitine alkaloids mesaconitine and benzoylmesaconine.
作者信息
Suzuki Y, Oyama T, Ishige A, Isono T, Asami A, Ikeda Y, Noguchi M, Omiya Y
机构信息
Pain Research Laboratory, Tsumura & Co., Ibaraki, Japan.
出版信息
Planta Med. 1994 Oct;60(5):391-4. doi: 10.1055/s-2006-959516.
We explored the possible role of the specific regions in the brain stem on the antinociceptive actions of mesaconitine (MA) and benzoylmesaconine (BM) by the microinjection of MA and BM into nucleus reticularis paragigantocellularis (NRPG), nucleus raphe magnus (NRM), and periaqueductal gray (PAG). MA microinjected into NRPG, NRM, or PAG elicited a dose-dependent antinociceptive action, whereas BM injected into NRM or PAG elicited a dose-dependent antinociceptive action but not in NRPG. The NRM appeared to be the most sensitive region among the three tested locations.
我们通过将中乌头碱（MA）和苯甲酰中乌头碱（BM）微量注射到巨细胞旁网状核（NRPG）、中缝大核（NRM）和导水管周围灰质（PAG），探讨了脑干特定区域在中乌头碱（MA）和苯甲酰中乌头碱（BM）抗伤害感受作用中的可能作用。微量注射到NRPG、NRM或PAG中的MA引发剂量依赖性抗伤害感受作用，而注射到NRM或PAG中的BM引发剂量依赖性抗伤害感受作用，但在NRPG中则不然。NRM似乎是三个测试部位中最敏感的区域。
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