Cai Shaohang, Liu Lili, Wu Xiaolu, Pan Ye, Yu Tao, Ou Hongjie
Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.
Patient Prefer Adherence. 2020 Aug 25;14:1533-1540. doi: 10.2147/PPA.S263007. eCollection 2020.
To investigate the levels of depression, anxiety, psychological symptoms and health-related quality of life (HRQOL) in people infected with human immunodeficiency virus (HIV) and to assess the risk factors.
A total of 121 people living with HIV (PLWHIV) were included, and 61 health individuals were selected as healthy controls. Their sociodemographic information was collected. The Self-Rating Depression Scale, Self-Rating Anxiety Scale, Symptom Checklist 90 and Short-Form Health Survey-36 were used.
The depression score was higher in PLWHIV (47.83 ± 10.58 vs 36.52 ± 9.69 P<0.001). Similar results were observed in anxiety score (41.06 ± 11.24 vs 32.31 ± 7.99, P<0.001). Multivariable analysis revealed that younger age (OR=0.929, P=0.004) and smoking (OR=4.297, P=0.001) were identified as independent factors of depression while young age (OR=0.890, P=0.008) and alcohol consumption (OR=4.801, P=0.002) were independent factors of anxiety. Results of SCL-90 questionnaire showed that hostility, paranoia ideation were significantly more pronounced when PLWHIV had depression. Results of HRQOL showed that physical functioning (82.88 ± 14.73 vs 93.41 ± 9.22, P<0.001) and mental health (57.46 ± 17.64 vs 65.68 ± 17.44, P=0.012) were lower in PLWHIV with depression. For PLWHIV with anxiety, vitality (56.96 ± 14.61 vs 67.58 ± 17.57, P=0.004), social functioning (64.52 ± 23.97 vs 74.64 ± 21.47, P=0.036) and mental health (52.57 ± 14.21 vs 65.03 ± 17.98, P=0.001) were lower. High depression level was showed the independent risk factor associated with poor HRQOL (OR=0.370, P=0.001).
Depression and anxiety were very common in PLWHIV. Physicians should not only focus on the antiviral treatment of these patients but also monitor their mental status, especially that of younger patients. For PLWHIV with depression and anxiety, psychological intervention should be provided, and social role rebuilding may be good for depression and anxiety alleviation.
调查人类免疫缺陷病毒（HIV）感染者的抑郁、焦虑、心理症状及健康相关生活质量（HRQOL）水平，并评估危险因素。
共纳入121例HIV感染者（PLWHIV），选取61例健康个体作为健康对照。收集他们的社会人口学信息。使用自评抑郁量表、自评焦虑量表、症状自评量表90和健康调查简表-36。
PLWHIV的抑郁得分更高（47.83±10.58 vs 36.52±9.69，P<0.001）。焦虑得分也有类似结果（41.06±11.24 vs 32.31±7.99，P<0.001）。多变量分析显示，年龄较小（OR=0.929，P=0.004）和吸烟（OR=4.297，P=0.001）被确定为抑郁的独立因素，而年龄较小（OR=0.890，P=0.008）和饮酒（OR=4.801，P=0.002）是焦虑的独立因素。SCL-90问卷结果显示，PLWHIV伴有抑郁时，敌对、偏执观念更为明显。HRQOL结果显示，伴有抑郁的PLWHIV的身体功能（82.88±14.73 vs 93.41±9.22，P<0.001）和心理健康（57.46±17.64 vs 65.68±17.44，P=0.012）较低。伴有焦虑的PLWHIV的活力（56.96±14.61 vs 67.58±17.57，P=0.004）、社会功能（64.52±23.97 vs 74.64±21.47，P=0.036）和心理健康（52.57±14.21 vs 65.03±17.98，P=0.001）较低。高抑郁水平是与HRQOL差相关的独立危险因素（OR=0.370，P=0.001）。
抑郁和焦虑在PLWHIV中非常常见。医生不仅应关注这些患者的抗病毒治疗，还应监测他们的心理状态，尤其是年轻患者。对于伴有抑郁和焦虑的PLWHIV，应提供心理干预，重建社会角色可能有助于缓解抑郁和焦虑。
