Amare Tadele, Getinet Wondale, Shumet Shegaye, Asrat Biksegn
Department of Psychiatry, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.
AIDS Res Treat. 2018 Feb 28;2018:5462959. doi: 10.1155/2018/5462959. eCollection 2018.
Depression is a substantial contributor to the global burden of disease and affects people in all communities across the globe. Depression is the most common psychiatric problem associated with HIV/AIDS and half of all PLWHIV with depression go underdiagnosed and untreated. Psychiatric complications of HIVAIDS delay mental health services in less affluent countries. However, there is lack of study with regard to the pooled estimation prevalence of depression in PLWHIV in Ethiopia.
The aim of this systematic review and meta-analysis is to summarize the most current available evidence from 2010 to March 2017 among adult PLWHIV in Ethiopia.
The team explored multiple databases searching methods including MEDLINE/PubMed, PsycINFO, Google Advance Scholar, and Google Scholar to find studies published with the data on the prevalence of depression among PLWHIV. We searched 150 research articles; of these 143 articles were excluded. Subsequently, thirteen articles were used for synthesis prevalence and four studies were included in the synthesis effect of sex on depression among PLWHIV.
The total of pooled estimated prevalence of depression in PLWHIV was 36.65. Estimated prevalence of depression in three studies by using CES-D was 31.19% and in six studies by using PHQ-9 was 37.91%. The remaining four studies used a single tool: Kessler-6 Scale (15.5%), HADS (41.2%), HDSQ (43.9%), and BDI (55.8%). Factors such as age, marital status, living alone, poor medication adherence, poor social support, clinical stages II and III of HIV, stigma, income, and occupation were significantly associated with depression.
The pooled estimate prevalence of depression among PLWHIV was higher than that in the general population. It is better to offer special attention to these populations.
抑郁症是全球疾病负担的重要因素，影响着全球所有社区的人们。抑郁症是与艾滋病毒/艾滋病相关的最常见精神问题，所有感染艾滋病毒的抑郁症患者中有一半未得到充分诊断和治疗。在较不富裕的国家，艾滋病毒/艾滋病的精神并发症会延迟心理健康服务。然而，埃塞俄比亚缺乏关于艾滋病毒感染者中抑郁症合并估计患病率的研究。
本系统评价和荟萃分析的目的是总结2010年至2017年3月埃塞俄比亚成年艾滋病毒感染者中最新可得的证据。
研究团队探索了多种数据库搜索方法，包括MEDLINE/PubMed、PsycINFO、谷歌高级学术搜索和谷歌学术搜索，以查找发表有关于艾滋病毒感染者抑郁症患病率数据的研究。我们搜索了150篇研究文章；其中143篇文章被排除。随后，13篇文章用于综合患病率分析，4项研究纳入了艾滋病毒感染者中性别对抑郁症影响的综合效应分析。
艾滋病毒感染者中抑郁症的合并估计总患病率为36.65。三项使用CES-D的研究中抑郁症的估计患病率为31.19%，六项使用PHQ-9的研究中为37.91%。其余四项研究使用了单一工具：凯斯勒6项量表（15.5%）、医院焦虑抑郁量表（41.2%）、家庭抑郁筛查问卷（43.9%）和贝克抑郁量表（55.8%）。年龄、婚姻状况、独居、药物依从性差、社会支持差、艾滋病毒临床分期II和III、耻辱感、收入和职业等因素与抑郁症显著相关。
艾滋病毒感染者中抑郁症的合并估计患病率高于一般人群。最好对这些人群给予特别关注。
