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受X连锁低磷性佝偻病影响的牙齿的成分和显微硬度研究结果。

Compositional and microhardness findings in tooth affected by X-linked hypophosphatemic rickets.

作者信息

Carvalho Francisco-Samuel-Rodrigues, Feitosa Victor-Pinheiro, Fonteles Cristiane-Sá Roriz, Ribeiro Thyciana-Rodrigues, Araújo Bruno-Sousa, Ayala Alejandro-Pedro, Costa Fábio-Wildson-Gurgel

机构信息

DDS, MSc. Division of Oral and Maxillofacial Surgery, Federal University of Ceará Campus Sobral, Sobral, Ceará, Brazil.

DDS, PhD. Research Division, Paulo Picanço School of Dentistry, Fortaleza, Brazil.

出版信息

J Clin Exp Dent. 2020 Jul 1;12(7):e688-e694. doi: 10.4317/jced.56945. eCollection 2020 Jul.

DOI:10.4317/jced.56945
PMID:32904979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7462373/
Abstract

BACKGROUND

This study aimed to evaluate the X-linked hypophosphatemic rickets (XLHR)-related compositional and microhardness tooth aspects.

MATERIAL AND METHODS

One affected and one non-affected teeth by XLHR were sectioned transversely, and each section was separated for Micro-Raman spectroscopy, Knoop microhardness and scanning electron microscopy with energy dispersive x-ray microanalysis (SEM-EDS). The outcomes of these analyses were assessed.

RESULTS

Outcomes of Raman analysis of inorganic/organic components (958/1250+1450 cm-1) and carbonate/phosphate (1070/~958 cm-1) ratios showed areas of altered enamel and dentin (interglobular dentin, calcospherites, and mantle dentin) with an increase of inorganic content in the rickets tooth. Microhardness reduction was observed in the affected tooth, with a more evident drop in regions of mantle dentin, interglobular dentin, and calcospherites. SEM-EDS analysis showed demonstrated the absence of calcium and phosphorus in interglobular spaces.

CONCLUSIONS

In conclusion, compositional and structural deficiencies were observed in deciduous tooth affected by XLHR. Also, it was observed the absence of hydroxyapatite in the interglobular dentin by using Raman spectroscopy analysis. Dentin, dentin permeability, X-linked hypophosphatemic rickets, tooth, tooth calcification, Raman spectroscopy.

摘要

背景

本研究旨在评估与X连锁低磷性佝偻病（XLHR）相关的牙齿成分和显微硬度方面。

材料与方法

将一颗受XLHR影响的牙齿和一颗未受影响的牙齿横向切片，每个切片分别用于显微拉曼光谱、努氏显微硬度测试以及带能谱分析的扫描电子显微镜（SEM-EDS）检测。对这些分析结果进行评估。

结果

无机/有机成分（958/1250+1450 cm-1）以及碳酸盐/磷酸盐（1070/~958 cm-1）比例的拉曼分析结果显示，佝偻病牙齿的釉质和牙本质（球间牙本质、钙球和罩牙本质）区域发生改变，无机成分增加。在患牙中观察到显微硬度降低，在罩牙本质、球间牙本质和钙球区域下降更为明显。SEM-EDS分析表明球间间隙中不存在钙和磷。

结论

总之，在受XLHR影响的乳牙中观察到成分和结构缺陷。此外，通过拉曼光谱分析观察到球间牙本质中不存在羟基磷灰石。牙本质、牙本质渗透性、X连锁低磷性佝偻病、牙齿、牙齿钙化、拉曼光谱。

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