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酷似巨细胞瘤的侵袭性指状乳头状腺癌——1例报告并文献复习

Aggressive Digital Papillary Adenocarcinoma Mimicking a Giant Cell Tumour - A Case Report and Review of the Literature.

作者信息

Joyce Kenneth, Leonard Niamh, Theopold Christoph

机构信息

Plastic, Reconstructive, and Aesthetic Surgery, Mater Hospital, Dublin, IRL.

Plastic and Reconstructive Surgery, Mater Hospital, Dublin, IRL.

出版信息

Cureus. 2020 Aug 3;12(8):e9531. doi: 10.7759/cureus.9531.

DOI:10.7759/cureus.9531
PMID:32905077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7465832/
Abstract

Aggressive digital papillary adenocarcinoma (ADPAca) is a rare, underreported, and often misdiagnosed malignant tumour of the eccrine sweat gland, with high recurrence and metastatic potential. We present a case of a painless mass over the middle phalanx of the dominant index finger in a 51-year-old man. The mass was present for over 20 years, which had slowly increased in size. The patient only presented when it began to interfere with his profession as an electrician. The clinical presentation was consistent with a giant cell tumour. Histological diagnosis was of an ADPAca. Staging investigations were negative and he subsequently went on to have a ray amputation. The importance of high clinical suspicion of digit lesions is highlighted. No specific histologic features have been identified to predict recurrence or metastasis. We review the merits of performing sentinel node biopsy and alternative treatment options such as Moh's micrographic surgery. We review the international literature to assess metastatic potential and follow-up requirements.

摘要

侵袭性指状乳头状腺癌(ADPAca)是一种罕见、报道不足且常被误诊的小汗腺恶性肿瘤,具有高复发和转移潜能。我们报告一例51岁男性患者,其优势示指中节指骨处出现无痛性肿块。该肿块已存在20多年,大小缓慢增加。患者直到它开始影响其电工职业时才前来就诊。临床表现与巨细胞瘤一致。组织学诊断为ADPAca。分期检查为阴性,随后他接受了截指手术。强调了对指部病变高度临床怀疑的重要性。尚未发现可预测复发或转移的特定组织学特征。我们回顾了进行前哨淋巴结活检的优点以及诸如莫氏显微外科手术等替代治疗方案。我们回顾国际文献以评估转移潜能和随访要求。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d44/7465832/324e7240e3df/cureus-0012-00000009531-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d44/7465832/738ccda57a03/cureus-0012-00000009531-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d44/7465832/c0e59ed90a03/cureus-0012-00000009531-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d44/7465832/74380f6bd9e0/cureus-0012-00000009531-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d44/7465832/92fb761cfeb0/cureus-0012-00000009531-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d44/7465832/4cde6baa9cae/cureus-0012-00000009531-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d44/7465832/324e7240e3df/cureus-0012-00000009531-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d44/7465832/738ccda57a03/cureus-0012-00000009531-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d44/7465832/c0e59ed90a03/cureus-0012-00000009531-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d44/7465832/74380f6bd9e0/cureus-0012-00000009531-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d44/7465832/92fb761cfeb0/cureus-0012-00000009531-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d44/7465832/4cde6baa9cae/cureus-0012-00000009531-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d44/7465832/324e7240e3df/cureus-0012-00000009531-i06.jpg

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本文引用的文献

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Br J Dermatol. 2019 May;180(5):1150-1160. doi: 10.1111/bjd.17446. Epub 2019 Jan 20.
2
Aggressive Digital Papillary Adenocarcinoma: Population-Based Analysis of Incidence, Demographics, Treatment, and Outcomes.侵袭性指状乳头状腺癌:基于人群的发病率、人口统计学、治疗及预后分析
Dermatol Surg. 2018 Jul;44(7):911-917. doi: 10.1097/DSS.0000000000001483.
3
Highly variable clinical feature and course of aggressive digital papillary adenocarcinoma.
侵袭性数字化乳头性腺瘤的临床表现和病程变化多样。
J Dermatol. 2018 Mar;45(3):357-360. doi: 10.1111/1346-8138.14159. Epub 2017 Nov 30.
4
Aggressive digital papillary adenocarcinoma: A clinicopathological study of 19 cases.侵袭性数码状乳头状腺癌:19 例临床病理研究。
J Am Acad Dermatol. 2017 Sep;77(3):549-558.e1. doi: 10.1016/j.jaad.2017.02.028. Epub 2017 May 9.
5
Mohs Micrographic Surgery as a Digit-Sparing Treatment for Aggressive Digital Papillary Adenocarcinoma.莫氏显微外科手术作为侵袭性指状乳头状腺癌的保指治疗方法
Dermatol Surg. 2017 Dec;43(12):1487-1489. doi: 10.1097/DSS.0000000000001070.
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Next-generation sequencing reveals rare genomic alterations in aggressive digital papillary adenocarcinoma.下一代测序揭示侵袭性指状乳头状腺癌中的罕见基因组改变。
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