Lisa Mona, Verma Pranab Kumar, Mustaqueem Syed Fiza
Department Pathology, Mahavir Cancer Sansthan, Phulwari Sharif, Patna, Bihar, India.
J Lab Physicians. 2020 Aug;12(2):103-110. doi: 10.1055/s-0040-1716633. Epub 2020 Sep 2.
The prevalent spectrum of the major subtypes of lymphoma varies across geographical regions. Through this study we aim to study the distribution of lymphoma in the state of Bihar by studying the immunophenotypic features and classifying them according to World Health Organization (WHO) 2017. To the best of our knowledge, this is the first study of this type from Bihar All the cases diagnosed as lymphoma between January 2016 and June 2019 in the Department of Pathology Mahavir Cancer Sansthan were included in the study. The cases were reviewed by two pathologists and diagnostically difficult cases were referred to higher center for opinion. A total of 518 cases were diagnosed as lymphoma. B cell lymphomas formed 79.1%, whereas T cell lymphomas formed 16.2% of the total. Hodgkin lymphoma (HL) was seen in 19.6% cases. Among the non-Hodgkin lymphoma (NHL), diffuse large B cell lymphoma was the most common subtype (58% of all NHLs). Follicular center-cell lymphomas, B cell small lymphocytic lymphoma, mantle-cell lymphoma, and marginal zone B cell lymphomas (including mucosa-associated lymphoid tissue lymphomas) amounted to 2.1, 6.9, 4.5, and 0.95%, respectively. Among the T cell lymphomas, T cell lymphoblastic lymphoma, anaplastic large-cell lymphomas of T/null-cell type, and other nodal peripheral T cell lymphomas accounted for 4.7, 8.1 and 6.6% of all cases, respectively. The prevalence of lymphoma subtypes in India is different from the rest of the world. We have analyzed the distribution of lymphomas in Bihar and compared it with other studies from India. Follicular lymphoma and mantle-cell lymphoma are less common in India compared with the west. Peripheral T cell lymphomas and T/NK-cell lymphomas of nasal types are less prevalent than some Asian countries but are more prevalent than the west. T cell lymphoblastic lymphoma and anaplastic large T/null cell lymphoma are more common in India.
淋巴瘤主要亚型的流行谱在不同地理区域有所不同。通过本研究，我们旨在通过研究免疫表型特征并根据世界卫生组织（WHO）2017年的标准对其进行分类，来研究比哈尔邦淋巴瘤的分布情况。据我们所知，这是比哈尔邦的首例此类研究。
2016年1月至2019年6月期间在马哈拉维癌症中心病理科诊断为淋巴瘤的所有病例均纳入本研究。病例由两名病理学家进行复查，诊断困难的病例转诊至上级中心征求意见。共诊断出518例淋巴瘤。
B细胞淋巴瘤占总数的79.1%，而T细胞淋巴瘤占16.2%。霍奇金淋巴瘤（HL）见于19.6%的病例。在非霍奇金淋巴瘤（NHL）中，弥漫性大B细胞淋巴瘤是最常见的亚型（占所有NHL的58%）。滤泡中心细胞淋巴瘤、B细胞小淋巴细胞淋巴瘤、套细胞淋巴瘤和边缘区B细胞淋巴瘤（包括黏膜相关淋巴组织淋巴瘤）分别占2.1%、6.9%、4.5%和0.95%。在T细胞淋巴瘤中，T细胞淋巴母细胞淋巴瘤、T/null细胞型间变性大细胞淋巴瘤和其他淋巴结外周T细胞淋巴瘤分别占所有病例的4.7%、8.1%和6.6%。
印度淋巴瘤亚型的患病率与世界其他地区不同。我们分析了比哈尔邦淋巴瘤的分布情况，并将其与印度其他研究进行了比较。与西方相比，滤泡性淋巴瘤和套细胞淋巴瘤在印度不太常见。外周T细胞淋巴瘤和鼻型T/NK细胞淋巴瘤的患病率低于一些亚洲国家，但高于西方。T细胞淋巴母细胞淋巴瘤和间变性大T/null细胞淋巴瘤在印度更为常见。
