Department of Endocrinology, the Second People's Hospital of Hefei, the Affiliated Hefei Hospital of Anhui Medical University, Hefei 230011, Anhui, China.
Department of Ultrasound, the Second People's Hospital of Hefei, the Affiliated Hefei Hospital of Anhui Medical University, Hefei 230011, Anhui, China..
Med Ultrason. 2020 Nov 18;22(4):393-401. doi: 10.11152/mu-2522. Epub 2020 Jun 29.
This study aims to evaluate and validate a simple quantitative ultrasound (US) method for determining the hepatic fat content (HFC) based on the combination of quantitative US hepatic/renal ratio (US-HRR) and quantitative US hepatic echo-intensity attenuation rate (US-HAR) as compared with [1H]-magnetic resonance spectroscopy (1H-MRS).
There were a total of 242 subjects recruited in the present study. All subjects were examined for HFC by quantitative US and 1H-MRS methods. The QUS-HRR and QUS-HAR were calculated from ordinary ultrasound images of liver and kidney with a triple modality 3D abdominal phantom using the Image J software.
The results found that US-HRR and US-HAR correlated with 1H-MRS HFC (US-HRR: r=0.946, p<0.001; US-HAR: r=0.936, p<0.001). The equation for HFC prediction by using quantitative US was: HFC (%) = 28.965 × US-HRR + 218.045 × US-HAR - 8.892. Subgroup analysis in study subjects with body mass index (BMI) ≥28 showed that quantitative US HFC was associated with 1H-MRS HFC (R2=0.953, p<0.001). Receiver operating characteristic (ROC) analysis observed that the cut-off value of fatty liver diagnosis was 6.71% in using the quantitative US model; the sensitivity and specificity for fatty liver diagnosis were 94.15% and 96.30%, respectively. Variability analysis indicated that there was a relative high degree of consistency in the measurement of HFC with different operators or ultrasonic apparatus.
Quantitative US measurement could be regarded as a simple, sensitive tool to accurately assess HFC. It provides a valid alternative to 1H-MRS as an easy, non-invasive option for the precise estimation of HFC in clinical practice.
本研究旨在评估和验证一种简单的定量超声（US）方法，用于确定肝脂肪含量（HFC），该方法基于定量 US 肝/肾比值（US-HRR）和定量 US 肝回声强度衰减率（US-HAR）的组合，并与 [1H]-磁共振波谱（1H-MRS）进行比较。
本研究共纳入 242 名受试者。所有受试者均通过定量 US 和 1H-MRS 方法进行 HFC 检查。使用 Image J 软件从肝脏和肾脏的普通超声图像以及三模态 3D 腹部体模中计算出 QUS-HRR 和 QUS-HAR。
结果发现，US-HRR 和 US-HAR 与 1H-MRS HFC 相关（US-HRR：r=0.946，p<0.001；US-HAR：r=0.936，p<0.001）。使用定量 US 预测 HFC 的方程为：HFC（%）=28.965×US-HRR+218.045×US-HAR-8.892。在 BMI≥28 的研究受试者亚组分析中，定量 US HFC 与 1H-MRS HFC 相关（R2=0.953，p<0.001）。受试者工作特征（ROC）分析观察到，使用定量 US 模型诊断脂肪肝的截断值为 6.71%；脂肪肝诊断的敏感性和特异性分别为 94.15%和 96.30%。变异性分析表明，不同操作者或超声设备对 HFC 的测量具有相对较高的一致性。
定量 US 测量可作为一种简单、敏感的工具，准确评估 HFC。它为临床实践中准确估计 HFC 提供了一种替代 1H-MRS 的有效方法，具有方便、非侵入性的优点。
