Department of Medical Biology, Faculty of Medicine, Balikesir University, Balikesir, Turkey.
Department of Chemistry, Faculty of Science and Literature, Balikesir University, Balikesir, Turkey.
J Biochem Mol Toxicol. 2021 Jan;35(1):e22628. doi: 10.1002/jbt.22628. Epub 2020 Sep 9.
The pathogenesis of nasal polyps is not completely understood. Oxidative damage contributes to polyp formation in the nasal mucosa. The paraoxonase 1 (PON1) enzyme is an important liver enzyme with high antioxidant activity. In this study, we investigated the correlation between Q192R genotypic polymorphism of the PON1 enzyme and nasal-polyp disease. The study examined 62 nasal-polyp patients and 88 controls. PON1 Q192R polymorphism was determined using polymerase chain reaction-restriction fragment length polymorphism. The genotype distribution of the PON1 gene was significantly different between nasal-polyp patients (QQ = 69.35%, QR = 25.81%, RR = 4.83%) and healthy controls (QQ = 52.27%, QR = 44.31%, RR = 3.40%). Our results suggest that the PON1 QQ genotype (odds ratio [OR] = 2.066, P = .036) is associated with a higher risk of developing the nasal-polyp disease while QR genotype (OR = 0.437, P = .021) showed a lower risk.
鼻息肉的发病机制尚不完全清楚。氧化损伤导致鼻黏膜息肉形成。对氧磷酶 1（PON1）酶是一种具有高抗氧化活性的重要肝脏酶。在这项研究中，我们研究了 PON1 酶的 Q192R 基因型多态性与鼻息肉病之间的相关性。该研究检查了 62 例鼻息肉患者和 88 例对照。使用聚合酶链反应-限制性片段长度多态性测定 PON1 Q192R 多态性。PON1 基因的基因型分布在鼻息肉患者（QQ=69.35%，QR=25.81%，RR=4.83%）和健康对照组（QQ=52.27%，QR=44.31%，RR=3.40%）之间有显著差异。我们的结果表明，PON1QQ 基因型（比值比[OR]=2.066，P=0.036）与发生鼻息肉病的风险增加相关，而 QR 基因型（OR=0.437，P=0.021）则显示出较低的风险。
