星形细胞通过丘脑的紧张性抑制控制感觉敏锐度。

Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus.

机构信息

Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea.

Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, Seoul 02792, South Korea; Center for Glia-Neuron Interaction, Korea Institute of Science and Technology, Seoul 02792, South Korea; Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, South Korea.

出版信息

Neuron. 2020 Nov 25;108(4):691-706.e10. doi: 10.1016/j.neuron.2020.08.013. Epub 2020 Sep 8.

DOI:10.1016/j.neuron.2020.08.013

PMID:32905785

Abstract

Sensory discrimination is essential for survival. However, how sensory information is finely controlled in the brain is not well defined. Here, we show that astrocytes control tactile acuity via tonic inhibition in the thalamus. Mechanistically, diamine oxidase (DAO) and the subsequent aldehyde dehydrogenase 1a1 (Aldh1a1) convert putrescine into GABA, which is released via Best1. The GABA from astrocytes inhibits synaptically evoked firing at the lemniscal synapses to fine-tune the dynamic range of the stimulation-response relationship, the precision of spike timing, and tactile discrimination. Our findings reveal a novel role of astrocytes in the control of sensory acuity through tonic GABA release.

摘要

感觉辨别对于生存至关重要。然而，大脑中如何精细控制感觉信息尚不清楚。在这里，我们发现星形胶质细胞通过丘脑的紧张性抑制来控制触觉的敏锐度。从机制上讲，二胺氧化酶（DAO）和随后的醛脱氢酶 1a1（Aldh1a1）将腐胺转化为 GABA，GABA 通过 Best1 释放。星形胶质细胞的 GABA 抑制了传入的lemniscal 突触的放电，从而精细调节了刺激-反应关系的动态范围、尖峰时间的精度和触觉辨别能力。我们的发现揭示了星形胶质细胞通过紧张性 GABA 释放来控制感觉敏锐度的新作用。