SOX2 与鳞状细胞癌。

SOX2 and squamous cancers.

机构信息

Department of Medicine, University of Cambridge, Addenbrookes Hospital, Box 157, Hills Rd, Cambridge, CB2 0QQ, United Kingdom.

出版信息

Semin Cancer Biol. 2020 Dec;67(Pt 1):154-167. doi: 10.1016/j.semcancer.2020.05.007. Epub 2020 Sep 6.

DOI:10.1016/j.semcancer.2020.05.007

PMID:32905832

Abstract

SOX2 is a pleiotropic nuclear transcription factor with major roles in stem cell biology and in development. Over the last 10 years SOX2 has also been implicated as a lineage-specific oncogene, notably in squamous carcinomas but also neurological tumours, particularly glioblastoma. Squamous carcinomas (SQCs) comprise a common group of malignancies for which there are no targeted therapeutic interventions. In this article we review the molecular epidemiological and laboratory evidence linking SOX2 with squamous carcinogenesis, explore in detail the multifaceted impact of SOX2 in SQC, describe areas of uncertainty and highlight areas for potential future research.

摘要

SOX2 是一种多效性核转录因子，在干细胞生物学和发育中具有重要作用。在过去的 10 年中，SOX2 也被认为是一种谱系特异性癌基因，特别是在鳞状细胞癌中，但也在神经肿瘤中，特别是胶质母细胞瘤中。鳞状细胞癌（SQCs）是一组常见的恶性肿瘤，目前尚无靶向治疗干预措施。本文综述了 SOX2 与鳞状细胞癌变相关的分子流行病学和实验室证据，详细探讨了 SOX2 在 SQC 中的多方面影响，描述了不确定领域，并强调了未来潜在研究的领域。