New York University, Department of Communicative Sciences and Disorders, 665 Broadway Suite 900, New York, NY 10012, USA.
New York University, Department of Communicative Sciences and Disorders, 665 Broadway Suite 900, New York, NY 10012, USA.
Brain Lang. 2020 Nov;210:104849. doi: 10.1016/j.bandl.2020.104849. Epub 2020 Sep 6.
This paper reports a feasibility study designed to evaluate the behavioral and neurological effects of using transcranial direct current stimulation (tDCS) in conjunction with speech motor learning treatment for individuals with acquired speech impairment subsequent to stroke. Most of the research using tDCS to enhance treatment outcomes in stroke recovery has focused on either limb motor control or aphasia treatment. Using a multiple-baseline multiple-probe crossover design, we compared both behavioral and brain connectivity-based outcomes following speech motor learning treatment with both Active tDCS and Sham tDCS. We observed that both treatment phases led to improvement in short-term maintenance, but that Active tDCS was associated with greater long-term maintenance improvement. Active tDCS was also associated with an increase in functional connectivity in the left hemisphere and interhemispherically in an ROI-based network analysis examining correlations among areas associated with speech production and acquired speech impairment. This report supports the possibility that tDCS may enhance both behavioral and neurological outcomes and indicates the importance of additional work in this area, although replication is required to confirm the extent and consistency of tDCS benefits on speech motor learning treatment outcomes.
本文报告了一项可行性研究，旨在评估经颅直流电刺激（tDCS）与言语运动学习治疗相结合，对中风后获得性言语障碍患者的行为和神经影响。大多数使用 tDCS 来提高中风康复治疗效果的研究都集中在肢体运动控制或失语症治疗上。本研究采用多基线多探针交叉设计，比较了在主动 tDCS 和假刺激 tDCS 两种情况下，言语运动学习治疗后的行为和基于脑连接的结果。我们观察到两种治疗阶段都导致短期维持的改善，但主动 tDCS 与长期维持的改善更相关。主动 tDCS 还与基于 ROI 的网络分析中左半球和半球间的功能连接增加相关，该分析检查了与言语产生和获得性言语障碍相关区域之间的相关性。本报告支持 tDCS 可能增强行为和神经结果的可能性，并表明在这一领域需要进一步的工作，尽管需要复制来确认 tDCS 对言语运动学习治疗结果的影响的程度和一致性。
