Neonatal Intensive Care Unit, Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.
Neonatal Intensive Care Unit, Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.
Early Hum Dev. 2020 Dec;151:105163. doi: 10.1016/j.earlhumdev.2020.105163. Epub 2020 Aug 20.
To compare body composition (BC) of premature infants at parenteral nutrition (PN) suspension and at term equivalent age (TEA).
Body weight, fat mass (FM), fat free mass (FFM) and FM as % of body weight were measured in infants born at <32 gestational weeks by air-displacement plethysmography at PN suspension and at TEA in a tertiary level hospital. Z-scores were calculated for BC and anthropometric measurements. Nutritional and clinical data were obtained during hospital stay. BC, weight and length were measured at birth in a sample of infants born at term for comparison.
Thirty premature infants with birth weight of 1198 ± 270 g and gestational age of 29.8 ± 1.8 weeks were included. At PN suspension, at 32.6 ± 1.6 postconceptional weeks, FFM z-score was similar to FFM z-score measured at TEA, at 39.8 ± 0.7 postconceptional weeks (-1.43 ± 1.27 vs -1.78 ± 1.64, p = 0.26), while FM z-score and %FM z-score at PN suspension were lower than those measured at TEA (FM z-score: 0.23 ± 0.62 versus 2.04 ± 1.00, p < 0.0001 and %FM z-score: 0.66 ± 0.76 versus 2.08 ± 1.07, p < 0.0001). At TEA, weight and length of premature infants were similar to those of term-born infants (3130 ± 340 g vs 3350 ± 340 g; 49.2 ± 2.4 cm vs 50.2 ± 2.5 cm, respectively), but %FM was higher (21.3 ± 4.2% vs 9.2 ± 4.4%, p < 0.001); higher exclusive enteral caloric and protein intakes were associated with a decrease in FM z-scores from PN suspension to TEA.
In our sample of premature infants, fat free mass z-score was similar, while fat mass and % fat mass z-scores increased substantially from parenteral nutrition suspension to term-equivalent age. Nutritional intakes during exclusive enteral nutrition did not seem to contribute to such increase.
比较早产儿在肠外营养（PN）暂停和达到胎龄（TEA）时的身体成分（BC）。
在一家三级医院，通过空气置换体描记法，对出生胎龄<32 周的婴儿在 PN 暂停时和 TEA 时测量体重、脂肪量（FM）、去脂体重（FFM）和 FM 占体重的百分比。对 BC 和人体测量值进行 Z 评分。在住院期间获得营养和临床数据。在 term 出生的婴儿样本中测量出生时的 BC、体重和长度进行比较。
纳入 30 名出生体重 1198±270g、胎龄 29.8±1.8 周的早产儿。在 PN 暂停时，在 32.6±1.6 个孕周时，FFM z 评分与在 TEA 时测量的 FFM z 评分相似（-1.43±1.27 与-1.78±1.64，p=0.26），而 FM z 评分和 %FM z 评分在 PN 暂停时低于在 TEA 时测量的 FM z 评分（FM z 评分：0.23±0.62 与 2.04±1.00，p<0.0001 和 %FM z 评分：0.66±0.76 与 2.08±1.07，p<0.0001）。在 TEA 时，早产儿的体重和长度与 term 出生的婴儿相似（3130±340g 与 3350±340g；49.2±2.4cm 与 50.2±2.5cm），但 %FM 更高（21.3±4.2%与 9.2±4.4%，p<0.001）；肠内营养的热量和蛋白质摄入增加与从 PN 暂停到 TEA 时 FM z 评分的降低有关。
在我们的早产儿样本中，去脂体重 z 评分相似，而脂肪量和 %脂肪量 z 评分从 PN 暂停到 TEA 时显著增加。肠内营养期间的营养摄入量似乎并没有导致这种增加。
