Research Division, Institute of Mental Health, Buangkok Green Medical Park, Singapore 539747, Singapore.
Int J Environ Res Public Health. 2020 Sep 7;17(18):6504. doi: 10.3390/ijerph17186504.
The experience of craving via exposure to drug-related cues often leads to relapse in drug users. This study consolidated existing empirical evidences of cue reactivity to methamphetamine to provide an overview of current literature and to inform the directions for future research. The best practice methodological framework for conducting scoping review by Arkey and O'Malley was adopted. Studies that have used a cue paradigm or reported on cue reactivity in persons with a history of methamphetamine use were included. Databases such as Medline, EMBASE, PsycINFO and CINAHL were searched using key terms, in addition to citation check and hand search. The search resulted in a total of 32 original research articles published between 2006 to 2020. Three main themes with regard to cue reactivity were identified and synthesized: (1) effects of cue exposure, (2) individual factors associated with cue reactivity, and (3) strategies that modulate craving or reactivity to cues. Exposure to methamphetamine-associated cues elicits significant craving and other autonomic reactivity. Evidence suggests that drug cue reactivity is strongly associated with indices of drug use and other individual-specific factors. Future studies should focus on high quality studies to support evidence-based interventions for reducing cue reactivity and to examine cue reactivity as an outcome measure.
暴露于与毒品相关的线索会引发吸毒者的觅药渴求，这种体验常常导致他们复吸。本研究整合了现有关于冰毒线索反应的实证证据，旨在提供当前文献综述，并为未来研究指明方向。研究采用了 Arkey 和 O'Malley 提出的用于开展范围综述的最佳实践方法框架。本研究纳入了使用线索范式或报告有冰毒使用史者线索反应的研究。除了使用关键词在 Medline、EMBASE、PsycINFO 和 CINAHL 等数据库中进行检索外，还进行了引文检索和手工检索。检索共得到了 2006 年至 2020 年间发表的 32 篇原始研究文章。根据线索反应，确定并综合了三个主要主题：（1）线索暴露的影响，（2）与线索反应相关的个体因素，（3）调节觅药渴求或线索反应的策略。暴露于与冰毒相关的线索会引起明显的觅药渴求及其他自主反应。有证据表明，药物线索反应与药物使用指标及其他个体特定因素密切相关。未来的研究应侧重于高质量的研究，以支持减少线索反应的循证干预，并将线索反应作为一种结果衡量指标进行研究。
