Anderson N E, Budde-Steffen C, Wiley R G, Thurman L, Rosenblum M K, Nadeau S E, Posner J B
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Neurology. 1988 Jul;38(7):1018-26. doi: 10.1212/wnl.38.7.1018.
An anti-Purkinje cell antibody was found in the serum and CSF of a man with adenocarcinoma of the lung and paraneoplastic cerebellar degeneration (PCD). This antibody differed from the autoantibodies found in patients with gynecologic cancer and PCD in that it produced a different pattern of Purkinje cell cytoplasmic staining, did not react with PCD antigens in Purkinje cell Western blots, and the antigen had a different species distribution. Unlike the antinuclear antibody found in patients with PCD and small-cell lung carcinoma, the antigen was restricted to the cytoplasm of Purkinje cells. If autoantibodies are important in the pathogenesis of PCD, this case illustrates that they can recognize different antigenic epitopes in the nervous system, but cause similar clinicopathologic syndromes.
在一名患有肺癌和副肿瘤性小脑变性（PCD）的男性患者的血清和脑脊液中发现了一种抗浦肯野细胞抗体。该抗体与妇科癌症和PCD患者中发现的自身抗体不同，因为它产生了不同的浦肯野细胞胞质染色模式，在浦肯野细胞蛋白质免疫印迹中不与PCD抗原反应，并且该抗原具有不同的物种分布。与PCD和小细胞肺癌患者中发现的抗核抗体不同，该抗原局限于浦肯野细胞的细胞质。如果自身抗体在PCD的发病机制中起重要作用，那么这个病例表明它们可以识别神经系统中的不同抗原表位，但会导致相似的临床病理综合征。
