Schmitz Julia, Gottschalk Kay-Eberhard
Applied Physics, LMU München, Amalienstr. 54, 80799 München, Germany.
Soft Matter. 2008 Jun 20;4(7):1373-1387. doi: 10.1039/b716805p.
Cellular adhesion against external forces is governed by both the equilibrium affinity of the involved receptor-ligand bonds and the mechanics of the cell. Certain receptors like integrins change their affinity as well as the mechanics of their anchorage to tune the adhesiveness. Whereas in the last few years the focus of integrin research has lain on the affinity regulation of the adhesion receptors, more recently the importance of cellular mechanics became apparent. Here, we focus on different aspects of the mechanical regulation of the cellular adhesiveness.
细胞对外部力量的黏附受所涉及的受体-配体键的平衡亲和力和细胞力学的共同支配。某些受体，如整合素，会改变其亲和力以及其锚定的力学特性来调节黏附性。在过去几年中，整合素研究的重点在于黏附受体的亲和力调节，而最近细胞力学的重要性变得明显。在这里，我们关注细胞黏附性机械调节的不同方面。
