Guo X, Qiu J, Ren J, Liu J C, Sun X D
Department of Immunization, Shanghai Municipal Center for Disease Control and Prevention， Shanghai 200336，China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2020 Sep 6;54(9):929-933. doi: 10.3760/cma.j.cn112150-20191011-00779.
To evaluate the safety of 23 Valent Pneumococcal Polysaccharide Vaccine (PPV23) among eldly people aged 60 and above in Shanghai. A total of 1 310 660 monitoring data of adverse events following immunization (AEFI) of PPV23 among people aged 60 and above were collected through the National AEFI Surveillance System from September 14, 2013 to December 31, 2017 in Shanghai. And the descriptive epidemiological methods were used for analysis. 433 cases of AEFI were reported from September 14, 2013 to December 31, 2017, with the incidence rate of AEFI was 33.04/100 000 doses. The general reactions were reported as 392 cases (90.53%), with 17 cases of abnormal reactions (3.93%), 23 cases of coincidences (5.31%) and 1 case of psychogenic reactions (0.23%). The reported incidence rates of general reactions and abnormal reactions of free PPV23 inoculation among elderly people in urban areas were 41.31 per 100 000 doses and 1.91/100 000 doses, respectively, which were higher than those in suburban areas (24.18/100 000 doses, 1.32/100 000 doses) and exurban areas (27.84/100 000 doses, 0.59/100 000 doses). The reported incidence rate of general reaction in females (35.38/100 000 doses) was higher than that in males (24.06/100 000 doses), and the reported incidence rate of abnormal reaction in males (1.58/100 000 doses) was higher than that in females (1.03/100 000 doses). The reported incidence rates of general and abnormal reactions were the highest in 60-64 years old group (62.65/100 000 doses and 4.87/100 000 doses, respectively). In addition, all patients with general reactions or abnormal reactions were better or cured. PPV23 vaccination is safe among people aged 60 and above in Shanghai.
评估23价肺炎球菌多糖疫苗（PPV23）在上海60岁及以上老年人中的安全性。2013年9月14日至2017年12月31日期间，通过国家预防接种异常反应（AEFI）监测系统收集了上海市60岁及以上人群PPV23免疫接种后AEFI的1310660条监测数据，并采用描述性流行病学方法进行分析。2013年9月14日至2017年12月31日共报告AEFI 433例，AEFI发生率为33.04/10万剂。其中一般反应报告392例（90.53%），异常反应17例（3.93%），偶合症23例（5.31%），心因性反应1例（0.23%）。城区老年人免费接种PPV23的一般反应和异常反应报告发生率分别为41.31/10万剂和1.91/10万剂，高于郊区（24.18/10万剂，1.32/10万剂）和远郊区（27.84/10万剂，0.59/10万剂）。女性一般反应报告发生率（35.38/10万剂）高于男性（24.06/10万剂），男性异常反应报告发生率（1.58/10万剂）高于女性（1.03/10万剂）。一般反应和异常反应报告发生率在60 - 64岁组最高（分别为62.65/10万剂和4.87/10万剂）。此外，所有一般反应或异常反应患者病情均好转或治愈。PPV23疫苗在上海60岁及以上人群中接种是安全的。
