Laboratory of Veterinary Clinical Parasitology, Federal University of Paraná, UFPR, Rua dos Funcionarios, 1540, Curitiba, PR, Brazil.
Ministry of Health, EPISUS, Esplanada dos Ministérios, Bloco G. Brasilia, DF, Brazil.
J Helminthol. 2020 Sep 10;94:e185. doi: 10.1017/S0022149X2000067X.
Fasciolosis is a food-borne disease that causes great distress to a range of hosts, including humans. The objectives of this study were to (1) evaluate the liver damage and carcass weight of cattle naturally infected with Fasciola hepatica from the state of Rio Grande do Sul (RS), Brazil, and to (2) determine the distribution of adult flukes in 12,236 cattle liver from RS. The data from these experiments were used to calculate the overall economic loss due to F. hepatica infection. Eighteen adult Polled Hereford cows were divided into a triclabendazole (TbG) and a F. hepatica-positive group (FhG). For Experiment 1, a generalized linear mixed model revealed a statistical difference in carcass weight (49.8 kg) between TbG and FhG. The Monte Carlo analysis also revealed that the animals' weight differences were due to the disease. For Experiment 2, the prevalence of infected livers was above 16% (1904/12,236), mostly (20.1%) from the south-west region of RS. The Susceptible-infected-recovered (SIR) epidemic model revealed the evolution of the infection using a high infectivity and low recovery rate. Other distinctive scenarios that occur in RS were also established with different rates of infectivity. The economic assessment showed a potential loss of US$45 million to the beef cattle industry of RS, with an overall State cost of US$90.3 million. These novel findings reveal the importance of fasciolosis infection, which can cause a significant health condition and poor animal welfare.
片形吸虫病是一种食源性疾病，给包括人类在内的多种宿主带来极大困扰。本研究的目的是：(1)评估巴西南里奥格兰德州（RS）自然感染肝片形吸虫的牛的肝脏损伤和胴体重；(2)确定 RS 地区 12236 头牛肝脏中成年片形吸虫的分布。这些实验的数据用于计算因肝片形吸虫感染而导致的总体经济损失。18 头无角海福特成年母牛被分为三氯苯达唑（TbG）和肝片形吸虫阳性组（FhG）。对于实验 1，广义线性混合模型显示 TbG 和 FhG 之间的胴体重存在统计学差异（49.8kg）。蒙特卡罗分析还表明，动物体重的差异是由于疾病造成的。对于实验 2，受感染肝脏的流行率超过 16%（1904/12236），主要来自 RS 的西南部地区。易感-感染-恢复（SIR）流行模型使用高感染率和低恢复率来显示感染的演变。还建立了 RS 地区其他具有不同感染率的不同情景。经济评估显示，RS 的肉牛产业可能损失 4500 万美元，州总成本为 9030 万美元。这些新发现揭示了片形吸虫感染的重要性，它可能导致严重的健康状况和动物福利不佳。
