Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
Department of Pathology, Toho University School of Medicine, Ota-ku, Tokyo, Japan.
J Clin Pathol. 2021 Sep;74(9):589-595. doi: 10.1136/jclinpath-2020-206457. Epub 2020 Sep 9.
L-type amino acid transporter 1 (LAT1) is a major Na-independent neutral amino acid transporter, forming a complex with CD98hc. The aim of this study is to investigate the significance of LAT1 and CD98hc in invasive breast cancer.
LAT1 and CD98hc expression was immunohistochemically assessed in 280 invasive breast cancers and analysed for association with clinicopathological features.
High levels of LAT1 and CD98hc were observed in triple-negative breast cancers (TNBCs) possessing negative immunoreactivity with oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2, compared with non-TNBCs (NTNBCs), and were associated with lymph-node metastasis and higher nuclear grade. The high-LAT1-expression group showed a poor prognosis in NTNBC and TNBC, however, high-CD98hc-expression group showed a poor prognosis only in NTNBC. LAT1 and CD98hc expression could be the prognostic factors in univariate analyses, but not in multivariate analyses. Further, we found that invasive tumour components showed higher LAT1 and CD98hc expression than non-invasive tumour components.
LAT1 and CD98hc may possess prognostic values in invasive breast cancer. LAT1 may be linked with cancer cell activities and disease progression in breast cancer.
L 型氨基酸转运蛋白 1（LAT1）是一种主要的 Na 非依赖性中性氨基酸转运蛋白，与 CD98hc 形成复合物。本研究旨在探讨 LAT1 和 CD98hc 在浸润性乳腺癌中的意义。
对 280 例浸润性乳腺癌进行 LAT1 和 CD98hc 的免疫组织化学评估，并分析其与临床病理特征的关系。
与非三阴性乳腺癌（NTNBC）相比，三阴性乳腺癌（TNBC）中 LAT1 和 CD98hc 的水平较高，这些乳腺癌对雌激素受体、孕激素受体和人表皮生长因子受体 2 的免疫反应为阴性，并且与淋巴结转移和核分级较高相关。高 LAT1 表达组在 NTB 和 TNBC 中预后不良，而高 CD98hc 表达组仅在 NTB 中预后不良。LAT1 和 CD98hc 的表达在单因素分析中是预后因素，但在多因素分析中不是。此外，我们发现侵袭性肿瘤成分的 LAT1 和 CD98hc 表达高于非侵袭性肿瘤成分。
LAT1 和 CD98hc 可能在浸润性乳腺癌中有预后价值。LAT1 可能与乳腺癌中癌细胞的活性和疾病进展有关。
