Greiner R, Thum P, Kann R
Schweizerisches Institut für Nuklearforschung-SIN, Medizinprojekt, Villigen.
Orthopade. 1988 Apr;17(2):182-92.
Radiotherapy is fully integrated in the treatment of soft tissue sarcomas. Nonamputative limb salvage is combined with large-volume, high-dose (65 Gy), pre- or postoperative radiotherapy. The survival rate for the conservative, combined approach to tumors of the extremities is no worse than that of radical or amputative surgery alone. It is better for large tumors to receive irradiation preoperatively, as there is then a higher probability that the limb can be spared at surgery. For tumors less than 10 cm, at doses of greater than 64 Gy radiotherapy alone can attain a local control rate of as much as 50%. With neutron irradiation, half of the patients with nonresectable tumors can be successfully treated locally. Conformal and dynamic treatment techniques will increase the probability that local tumors can be controlled by irradiation alone. The pion treatment technique at SIN is described in some detail.
放射治疗已完全融入软组织肉瘤的治疗中。非截肢性保肢治疗与大体积、高剂量（65 Gy）的术前或术后放射治疗相结合。对于四肢肿瘤采用保守性联合治疗方法的生存率并不比单独进行根治性手术或截肢手术差。对于大肿瘤，术前进行放疗更好，因为这样在手术时保留肢体的可能性更高。对于小于10 cm的肿瘤，单独放疗剂量大于64 Gy时，局部控制率可达50%。采用中子照射，一半不可切除肿瘤的患者可获得局部成功治疗。适形和动态治疗技术将提高仅通过照射就能控制局部肿瘤的可能性。文中对瑞士保罗谢尔研究所的π介子治疗技术进行了较为详细的描述。
