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高钙血症在晚期前列腺腺癌患者中的意义尚不明确。

Hypercalcemia Is of Uncertain Significance in Patients With Advanced Adenocarcinoma of the Prostate.

作者信息

Alhatemi Ghaith, Alhatemi Rafal, Aldiwani Haider, Hussein Marwah, Levi Edi, Jasti Pallavi

机构信息

and are Internists and is a Research Assistant, all at the Detroit Medical Center, Wayne State University in Michigan. is an Internist at Scripps Mercy Hospital Chula Vista in San Diego, California. is a Pathologist and is a Medical Oncologist, both at John Dingell VA Medical Center in Detroit.

出版信息

Fed Pract. 2020 Jul;37(7):320-324.

PMID:32908336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7473718/
Abstract

Hypercalcemia in the setting of prostate cancer is rare with an uncertain pathophysiology and more research is needed into the role of parathyroid hormone-related peptide as a growth factor and possibly target-directed monoclonal antibody therapies.

摘要

前列腺癌患者出现高钙血症的情况较为罕见，其病理生理学尚不明确，甲状旁腺激素相关肽作为一种生长因子的作用以及可能的靶向单克隆抗体疗法仍需更多研究。

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Hypercalcemia Is of Uncertain Significance in Patients With Advanced Adenocarcinoma of the Prostate.高钙血症在晚期前列腺腺癌患者中的意义尚不明确。
Fed Pract. 2020 Jul;37(7):320-324.
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Hypercalcemia in prostate cancer with positive neuron-specific enolase stain.
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Parathyroid hormone-related protein expression in human gastric adenocarcinomas not associated with hypercalcemia.甲状旁腺激素相关蛋白在非高钙血症相关性人胃腺癌中的表达
Am J Gastroenterol. 1995 Oct;90(10):1864-7.
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Passive immunization with anti-parathyroid hormone-related protein monoclonal antibody markedly prolongs survival time of hypercalcemic nude mice bearing transplanted human PTHrP-producing tumors.用抗甲状旁腺激素相关蛋白单克隆抗体进行被动免疫可显著延长携带移植的人甲状旁腺激素相关蛋白产生肿瘤的高钙血症裸鼠的存活时间。
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Contribution of parathyroid hormone-related peptide to the evaluation of hypercalcemia.甲状旁腺激素相关肽在高钙血症评估中的作用。
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Hypercalcemia in Urological Malignancies: A Review.泌尿系统恶性肿瘤中的高钙血症：综述
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Recurrent hypercalcaemia in a patient with dual urological malignancies: A rare life-threatening entity.一名患有双泌尿系统恶性肿瘤患者的复发性高钙血症：一种罕见的危及生命的病症。
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本文引用的文献

1
Hypercalcemia due to parathyroid hormone-related peptide secreted by neuroendocrine dedifferentiated prostate cancer.神经内分泌去分化前列腺癌分泌甲状旁腺激素相关肽所致的高钙血症
Urol Case Rep. 2018 Nov 9;22:67-69. doi: 10.1016/j.eucr.2018.11.001. eCollection 2019 Jan.
2
Prevalence of hypercalcemia among cancer patients in the United States.美国癌症患者高钙血症的患病率。
Cancer Med. 2016 Aug;5(8):2091-100. doi: 10.1002/cam4.749. Epub 2016 Jun 5.
3
Cancer-Related Hypercalcemia.癌症相关高钙血症
J Oncol Pract. 2016 May;12(5):426-32. doi: 10.1200/JOP.2016.011155.
4
Meta-Analysis Evaluating the Impact of Site of Metastasis on Overall Survival in Men With Castration-Resistant Prostate Cancer.评估转移部位对去势抵抗性前列腺癌男性患者总生存期影响的Meta分析
J Clin Oncol. 2016 May 10;34(14):1652-9. doi: 10.1200/JCO.2015.65.7270. Epub 2016 Mar 7.
5
Overview of prostate-specific membrane antigen.前列腺特异性膜抗原概述
Rev Urol. 2004;6 Suppl 10(Suppl 10):S13-8.
6
Cytokeratin 7 and 20 staining for the diagnosis of lung and colorectal adenocarcinoma.细胞角蛋白7和20染色在肺和结肠直肠腺癌诊断中的应用
Br J Cancer. 2002 Jun 17;86(12):1884-7. doi: 10.1038/sj.bjc.6600326.
7
Hypercalcemia of malignancy.恶性肿瘤高钙血症
Rev Endocr Metab Disord. 2000 Nov;1(4):253-63. doi: 10.1023/a:1026597816193.
8
Immunohistochemical localization of parathyroid hormone-related protein in human prostate cancer.
Cancer Res. 1993 Apr 15;53(8):1724-6.
9
Parathyroid hormone-related protein: a potential autocrine growth regulator in human prostate cancer cell lines.甲状旁腺激素相关蛋白：人前列腺癌细胞系中一种潜在的自分泌生长调节因子。
Urology. 1994 May;43(5):675-9. doi: 10.1016/0090-4295(94)90183-x.
10
Metastatic carcinoma of the prostate with hypercalcemia.伴有高钙血症的前列腺转移性癌
Cleve Clin J Med. 1990 Oct;57(7):636-8. doi: 10.3949/ccjm.57.7.636.