Goldman J M
Royal Postgraduate Medical School, London, England.
Nouv Rev Fr Hematol (1978). 1988;30(1-2):31-3.
In patients with chronic myeloid leukaemia in chronic phase treated by allogeneic transplantation using unmanipulated donor marrow cells the incidence of cytogenetic or haematological relapse is low. Occasional Ph positive metaphases have been identified in the marrow without subsequent evolution to haematological or clinical relapse. In contrast in patients transplanted with marrow depleted of T-cells Ph-positive cells are found frequently in the marrow and subsequent progression to haematological relapse is relatively common. These observations strongly support the concept of a graft-versus-leukaemia effect mediated by T-lymphocytes or by cells with a similar membrane phenotype.
在使用未处理的供体骨髓细胞进行异基因移植治疗的慢性期慢性髓性白血病患者中，细胞遗传学或血液学复发的发生率较低。偶尔在骨髓中可发现Ph阳性中期细胞，但随后并未发展为血液学或临床复发。相比之下，在移植了去除T细胞的骨髓的患者中，骨髓中经常发现Ph阳性细胞，随后进展为血液学复发相对常见。这些观察结果有力地支持了由T淋巴细胞或具有相似膜表型的细胞介导的移植物抗白血病效应的概念。
