Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100005 Beijing, China.
Mediators Inflamm. 2020 Aug 18;2020:5230716. doi: 10.1155/2020/5230716. eCollection 2020.
Interleukin-33 (IL-33), an important member of the IL-1 family, plays a pivotal role in regulating immune responses via combining with its receptor suppression of tumorigenicity 2 (ST2). We have already known IL-33/ST2 axis participates in the pathogenesis of various diseases, including liver diseases, renal diseases, and neurological diseases. Recently, emerging studies are indicating that IL-33/ST2 is also involved in a wide range of ocular diseases, such as allergic eye disease, keratitis and corneal regeneration, dry eye disease, uveitis, vitreoretinal diseases, and neuromyelitis optica spectrum disorder. In this review, we will summarize and discuss the current understanding about the functional roles of IL-33/ST2 in eyes, with an attempt to explore the possible study perspectives and therapeutic alternatives in the future.
白细胞介素-33（IL-33）是 IL-1 家族的重要成员，通过与其受体抑制肿瘤发生 2（ST2）结合，在调节免疫反应方面发挥着关键作用。我们已经知道 IL-33/ST2 轴参与了各种疾病的发病机制，包括肝脏疾病、肾脏疾病和神经疾病。最近，新的研究表明，IL-33/ST2 也参与了广泛的眼部疾病，如过敏性眼病、角膜炎和角膜再生、干眼症、葡萄膜炎、玻璃视网膜疾病和视神经脊髓炎谱系障碍。在这篇综述中，我们将总结和讨论目前对 IL-33/ST2 在眼睛中的功能作用的认识，并试图探讨未来可能的研究视角和治疗选择。
