Wang Cuiying, Yue Chang-Duo, Yuan Jia, Zheng Jia-Lian, Zhang Ying, Yu Hong, Chen Jian, Meng Sixuan, Yu Yang, Yu Guang-Ao, Che Chi-Ming
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, and Chemical Biology Center, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Chem Commun (Camb). 2020 Oct 11;56(79):11775-11778. doi: 10.1039/d0cc05340f. Epub 2020 Sep 10.
An efficient C-P coupling reaction of enantiopure tert-butylmethylphosphine-boranes with aryl and heteroaryl halides is developed by using Pd(OAc)/dppf as a catalyst, affording a series of (S) or (R)-P-chiral phosphines in moderate to high yields and with ee values up to 99% ee. Moreover, the reaction time could be reduced from 72 h to 6 h with increased ee values under microwave irradiation.
通过使用Pd(OAc)/dppf作为催化剂，开发了一种对映纯叔丁基甲基膦硼烷与芳基和杂芳基卤化物的高效C-P偶联反应，以中等到高的产率得到了一系列(S)或(R)-P-手性膦，对映体过量值高达99%ee。此外，在微波辐射下，反应时间可以从72小时减少到6小时，同时对映体过量值增加。
