Liu Wenjie, Xu Jiamin, Chen Xiahong, Zhang Fuxing, Xu Zhifeng, Wang Deping, He Yongqiang, Xia Xiaohong, Zhang Xin, Liang Yun
Key Laboratory of Functional Organometallic Materials, College of Chemistry and Materials Science, Hengyang Normal University, Hengyang 421008, Hunan Province, PR China.
College of Materials Science and Engineering, Hunan University, Changsha 410082, PR China.
Org Lett. 2020 Oct 2;22(19):7486-7490. doi: 10.1021/acs.orglett.0c02672. Epub 2020 Sep 10.
A class of 2-aminopyridine 1-oxides are discovered to be effective ligands for the Cu-catalyzed amination of less reactive (hetero)aryl chlorides. A wide range of functionalized (hetero)aryl chlorides reacted with various aliphatic amines to afford the desired products in good to excellent yields under the catalyst of CuI/2-aminopyridine 1-oxides. Furthermore, the catalyst system worked well for the coupling of cyclic secondary amines and -methyl benzylamine with (hetero)aryl chlorides.
发现一类2-氨基吡啶1-氧化物是铜催化的低活性（杂）芳基氯化物胺化反应的有效配体。在CuI/2-氨基吡啶1-氧化物催化剂作用下，多种官能化的（杂）芳基氯化物与各种脂肪族胺反应，以良好至优异的产率得到所需产物。此外，该催化体系在环状仲胺和α-甲基苄胺与（杂）芳基氯化物的偶联反应中也表现良好。
