帕金森病中的多巴胺受体
Dopamine receptors in Parkinson's disease.
作者信息
Hassan M N, Thakar J H
机构信息
Parkinson's Disease Research Laboratory, Ottawa Civic Hospital, Ontario, Canada.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(2-3):173-82. doi: 10.1016/0278-5846(88)90035-8.
PMID:3290993
Abstract
- Parkinson's disease is associated with profound decreases in striatal dopamine concentrations. 2. There are significant increases in the densities of striatal D1 and D2 receptors as part of the compensatory mechanism. 3. Levodopa therapy induces a down-regulation of both D1 and D2 receptors to normal densities. 4. Positron emission tomography detects striatal changes in early Parkinson's disease or toxin-induced parkinsonism.
摘要
- 帕金森病与纹状体多巴胺浓度的显著降低有关。2. 作为代偿机制的一部分，纹状体D1和D2受体密度显著增加。3. 左旋多巴治疗可使D1和D2受体下调至正常密度。4. 正电子发射断层扫描可检测早期帕金森病或毒素诱导的帕金森综合征中的纹状体变化。
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