Division of Medical Oncology, Department of Medicine, University of the Philippines-Philippine General Hospital, Manila, Philippines.
J Immunother. 2021 Jan;44(1):29-40. doi: 10.1097/CJI.0000000000000331.
Tumor-infiltrating lymphocytes (TILs) play an important role in mediating treatment response in pancreatic cancer. This meta-analysis investigated the prognostic significance of TIL subsets on overall survival (OS) and disease-free survival (DFS) of patients with pancreatic cancer. Studies were gathered via search of PubMed, Google Scholar, and Cochrane Library databases up to August 1, 2019. Using Review Manager version 5.3.5, pooled hazard ratios and 95% confidence intervals (CIs) were calculated using random or fixed-effects models, depending on the heterogeneity of studies. A total of 11 studies comprising 1760 patients were included in the meta-analysis. Pooled analysis revealed that high CD8 TILs were associated with improved OS [hazard ratio (HR)=0.59, 95% CI=0.51-0.69, P<0.00001] and DFS (HR=0.60, 95% CI=0.50-0.73, P<0.00001). Similarly, high CD3 TILs correlated with better OS (HR=0.64, 95% CI=0.54-0.75, P<0.00001) and DFS (HR=0.53, 95% CI=0.31-0.92, P<0.0001). In contrast, high FoxP3 TILs were associated with worse OS (HR=1.39, 95% CI=1.03-1.88, P=0.03). Finally, high CD4 TILs showed significant improvement in OS (HR=0.74, 95% CI=0.63-0.86, P=0.0001). TILs are a promising prognostic biomarker in pancreatic cancer. Prospective studies evaluating TILs are recommended as well as the establishment of standards in the assessment of TILs.
肿瘤浸润淋巴细胞（TILs）在介导胰腺癌治疗反应中发挥重要作用。本荟萃分析研究了 TIL 亚群对胰腺癌患者总生存（OS）和无病生存（DFS）的预后意义。通过搜索 PubMed、Google Scholar 和 Cochrane Library 数据库，收集截至 2019 年 8 月 1 日的研究。使用 Review Manager 版本 5.3.5，根据研究的异质性，使用随机或固定效应模型计算合并的风险比和 95%置信区间（CI）。共有 11 项研究，包含 1760 例患者，纳入荟萃分析。合并分析显示，高 CD8 TILs 与 OS 改善相关[风险比（HR）=0.59，95%CI=0.51-0.69，P<0.00001]和 DFS（HR=0.60，95%CI=0.50-0.73，P<0.00001）。同样，高 CD3 TILs 与更好的 OS（HR=0.64，95%CI=0.54-0.75，P<0.00001）和 DFS（HR=0.53，95%CI=0.31-0.92，P<0.0001）相关。相反，高 FoxP3 TILs 与 OS 较差相关（HR=1.39，95%CI=1.03-1.88，P=0.03）。最后，高 CD4 TILs 显示 OS 显著改善（HR=0.74，95%CI=0.63-0.86，P=0.0001）。TILs 是胰腺癌有前途的预后生物标志物。建议进行评估 TILs 的前瞻性研究，并建立 TILs 评估的标准。
