Majewski F
Monatsschr Kinderheilkd (1902). 1977 Jun;125(6):609-20.
In a survey of the literature the teratogenic effects of radiation and some drugs are discussed. Teratogenicity is proved for thalidomide, aminopterin, busulfan, cyclophosphamide, chlorambucil, mercaptopurin and diphenylhydantoin, trimethadione and warfarin. After the thalidomide-tragedy drug-induced malformations of the embryo are extremely rare, whereas malformations due to alcohol are rather frequent. Own experiences with more than 70 patients with alcoholembryopathy are reported. Nicotin seems not to be teratogenic, but due to nicotin the perinatal mortality is elevated. The questionable teratogenic effects of Heroin and LSD are discussed.
在一项文献调查中，讨论了辐射和某些药物的致畸作用。已证实沙利度胺、氨甲蝶呤、白消安、环磷酰胺、苯丁酸氮芥、巯嘌呤、苯妥英、三甲双酮和华法林具有致畸性。沙利度胺悲剧之后，药物引起的胚胎畸形极为罕见，而酒精引起的畸形则相当常见。报告了对70多名患有酒精胚胎病患者的自身经验。尼古丁似乎没有致畸性，但由于尼古丁，围产期死亡率会升高。讨论了海洛因和麦角酸二乙胺可疑的致畸作用。
