氨预测乙型肝炎病毒相关慢加急性肝衰竭患者的不良结局。
Ammonia predicts poor outcomes in patients with hepatitis B virus-related acute-on-chronic liver failure.
机构信息
Department of Clinical Laboratory, Shengzhou People's Hospital, Shengzhou Branch of the First Affiliated Hospital of Zhejiang University, Shengzhou, China.
Department of Clinical Laboratory, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
出版信息
J Clin Lab Anal. 2020 Dec;34(12):e23553. doi: 10.1002/jcla.23553. Epub 2020 Sep 11.
BACKGROUND
Hepatic encephalopathy (HE) is a common feature of acute liver failure and has been reported to be associated with poor outcomes. Ammonia is thought to be central to the pathogenesis of HE, but its role in hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is unclear. The present study aimed to assess the prognostic role of ammonia level for patients with HBV-ACLF.
METHODS
We retrospectively recruited 127 patients diagnosed with HBV-ACLF for the present study.
RESULTS
Ammonia levels at the time of admission were higher among non-surviving participants than in survivors. Increased ammonia level was found to be associated with severe liver disease and was identified as an independent predictor for mortality in patients with HBV-ACLF.
CONCLUSIONS
Our results suggest that high ammonia level at admission is an independent factor for predicting short-term mortality in patients with HBV-ACLF. Therefore, ammonia levels may represent a therapeutic target for this condition.
背景
肝性脑病（HE）是急性肝功能衰竭的常见特征，有报道称其与不良预后相关。氨被认为是 HE 发病机制的核心，但在乙型肝炎病毒相关慢加急性肝衰竭（HBV-ACLF）中的作用尚不清楚。本研究旨在评估氨水平对 HBV-ACLF 患者的预后作用。
方法
我们回顾性招募了 127 名诊断为 HBV-ACLF 的患者进行本研究。
结果
入院时非存活组患者的氨水平高于存活组。高氨水平与严重肝病相关，并且是 HBV-ACLF 患者死亡的独立预测因素。
结论
我们的研究结果表明，入院时高氨水平是预测 HBV-ACLF 患者短期死亡率的独立因素。因此，氨水平可能是该疾病的治疗靶点。
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