Poeck K
Department of Neurology, RWTH Aachen, FR Germany.
Acta Neurol Belg. 1988 Jan-Feb;88(1):35-45.
Intraarterial thrombolytic therapy by means of urokinase has proved to be effective and safe in certain instances of acute thromboembolic occlusion of the vertebral and/or the basilar artery. Small hemorrhages have not led to deterioration in the patients' neurological state. In the territory of the carotid artery local thrombolytic therapy may be effective in very selected cases of acute thromboembolic occlusion. There is a high risk of intracerebral hemorrhage. Possibly intravenous administration of tPA will replace local intraarterial thrombolysis, provided a strict regimen is established for selection of patients, determination of dosage and time constraints for the application of this therapy.
事实证明，在某些椎动脉和/或基底动脉急性血栓栓塞性闭塞的病例中，通过尿激酶进行动脉内溶栓治疗是有效且安全的。小出血并未导致患者神经状态恶化。在颈动脉区域，局部溶栓治疗在极少数急性血栓栓塞性闭塞病例中可能有效。但存在脑出血的高风险。如果能制定严格的方案用于患者选择、剂量确定以及该治疗应用的时间限制，静脉注射组织型纤溶酶原激活剂（tPA）可能会取代局部动脉内溶栓治疗。
