Giovannini P, Scigliano G, Piccolo I, Soliveri P, Suchy I, Caraceni T
Department of Neurology, Institute of Neurology, C. Besta, Milan, Italy.
Acta Neurol Scand. 1988 Apr;77(4):322-7. doi: 10.1111/j.1600-0404.1988.tb05916.x.
Lisuride at a mean daily dose of 3.2 mg was given to 15 untreated idiopathic Parkinson's disease patients. There were 10 dropouts, due mainly to inefficacy in the first months of therapy. The parkinsonian pattern in the patients who remained in the study for the full 4 years showed distinct improvement, which was maintained for less than 2 years. The patients did not develop "on-off" phenomena or abnormal involuntary movements during follow-up.
将平均每日剂量为3.2毫克的利苏立得给予15名未经治疗的特发性帕金森病患者。有10名患者退出，主要是因为在治疗的头几个月疗效不佳。在整个4年研究期间持续参与的患者的帕金森病症状模式有明显改善，且这种改善持续了不到2年。在随访期间，患者未出现“开-关”现象或异常不自主运动。
