Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.
Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Nutr Metab Cardiovasc Dis. 2020 Nov 27;30(12):2221-2229. doi: 10.1016/j.numecd.2020.07.009. Epub 2020 Jul 17.
Intentional weight loss may reduce symptom severity of atrial fibrillation (AF) in relatively young AF patients with overweight. We examined whether symptom severity and quality of life (QoL) are associated with weight status in the general population with AF.
Patients with electrocardiogram-confirmed AF completed validated questionnaires: the EuroQol 5 Dimensions QoL questionnaire and the Toronto Atrial Fibrillation Severity Scale (AFSS). The AFSS assessed the AF burden scoring on AF-related symptoms and the total AF burden measured as a combination of duration, frequency, and severity of an irregular heartbeat. Generalized liner models examined the association of body mass index (BMI) with AF severity and QoL adjusting for confounders. Between 2018 and 2019, 882 of 1901 (46%) mailed questionnaires were returned completed. Participants had a mean (SD) age of 74 (10) years old and a BMI of 27.4 (5.6) kg/m. Sixteen percent reported having never experienced an irregular heartbeat. A 5 kg/m higher BMI was associated with a 0.65 (95%CI: 0.25 to 1.06) higher symptom score, where 3 points represent a clinically relevant change in state. A 5 kg/m higher BMI was associated with a -1.61 (95%CI: -2.72 to -0.50) lower QoL score. The coefficient of the total AF burden for a 5 kg/m higher BMI was 0.17 (95% CI: -0.01 to 0.68).
BMI was positively associated with symptoms and negatively associated with one of the two measures of QoL, but not with the total AF burden. However, the strength of association was small and not clinically meaningful.
有超重的相对年轻的房颤（AF）患者，通过有意减重可能会减轻房颤症状的严重程度。我们研究了一般房颤人群的体重状况是否与症状严重程度和生活质量（QoL）有关。
心电图确诊为房颤的患者完成了经过验证的问卷：欧洲五维健康量表（EQ-5D）和多伦多房颤严重程度量表（AFSS）。AFSS 根据与房颤相关的症状对房颤负担进行评分，总房颤负担则通过不规则心跳的持续时间、频率和严重程度的组合来衡量。广义线性模型通过调整混杂因素，研究了体重指数（BMI）与房颤严重程度和 QoL 的关系。2018 年至 2019 年，1901 份邮寄问卷中有 882 份（46%）被寄回并填写完整。参与者的平均（标准差）年龄为 74（10）岁，BMI 为 27.4（5.6）kg/m2。16%的人报告从未经历过不规则心跳。BMI 每增加 5kg/m2，症状评分就会增加 0.65（95%CI：0.25 至 1.06），其中 3 分代表状态的临床相关变化。BMI 每增加 5kg/m2，QoL 评分就会降低 1.61（95%CI：-2.72 至 -0.50）。BMI 每增加 5kg/m2，总房颤负担的系数为 0.17（95%CI：-0.01 至 0.68）。
BMI 与症状呈正相关，与两种 QoL 测量指标中的一种呈负相关，但与总房颤负担无关。然而，关联的强度很小，且无临床意义。
