Ernst A, Taube C, Lotz P, Mest H J
ENT Clinic, Martin Luther University, Halle/Saale, German Democratic Republic.
Arch Otorhinolaryngol. 1988;245(1):50-2. doi: 10.1007/BF00463549.
Dazoxiben, a thromboxane synthetase inhibitor, was infused i.v. in a first group of guinea pigs. Saline was given to a second group of animals as controls. Subsequently, the lateral cochlear walls of each animal were prepared and analyzed for thromboxane (TXA) and prostacyclin (PGI) using radioimmunoassay. These studies showed that dazoxiben crosses the blood-labyrinth barrier and shifts the TXA2/PGI2 balance in favor of the latter. The effects demonstrated are discussed with respect to the relevance of prostanoids in cochlear physiology.
第一组豚鼠静脉注射血栓素合成酶抑制剂达唑氧苯。第二组动物注射生理盐水作为对照。随后，制备每只动物的耳蜗外侧壁，并用放射免疫分析法分析血栓素（TXA）和前列环素（PGI）。这些研究表明，达唑氧苯可穿过血迷路屏障，使TXA2/PGI2平衡向有利于后者的方向转变。结合类前列腺素在耳蜗生理学中的相关性，对所展示的效应进行了讨论。
