School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai 200032, China.
School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai 200032, China; Zhejiang Provincial Center for Disease Control and Prevention, No.3399 Binsheng Road, Hangzhou 310051, China.
Environ Int. 2020 Dec;145:106105. doi: 10.1016/j.envint.2020.106105. Epub 2020 Sep 9.
Early-life carbamate exposure during developmental period has been linked with adverse health effects and attracted attention.
Three hundred and three children at age of seven were included in the current study. Urinary carbofuranphenol concentrations were measured using gas chromatography-tandem mass spectrometry. Verbal, performance and full-scale intelligence quotients (IQ, IQ, and IQ) were assessed using Wechsler Intelligence Scale for Children-Chinese Revised. Generalized linear models were used to explore the associations between carbofuranphenol levels and IQs. Generalized estimating equations were used to explore long-term health effect and sensitive time window.
Carbofuranphenol was detected in 96.6% of the seven-year-old urinary samples, the geometric mean, median, and inter quartile range of the carbofuranphenol concentrations were 0.67 μg/L, 0.30 μg/L, and 0.09-3.72 μg/L, respectively, which were similar with the level of three-year-old children from the SMBCS cohort. Seven-year-old carbofuranphenol level was negatively associated with IQ [β = -0.044; 95% confidence interval (CI): -0.087, -0.001; p = 0.045]. Three-year-old carbofuranphenol level was negatively associated with IQ (β = -0.100; 95% CI: -0.186, -0.014; p = 0.022) and IQ (β = -0.087; 95% CI: -0.173, -0.001; p = 0.047). Carbamate exposure of maternal and children at both three and seven years old had negative associations with IQ (β = -0.089; 95% CI: -0.171, -0.007; p = 0.034), and IQ (β = -0.064; 95% CI: -0.127, -0.000; p = 0.049) of children at age of seven.
Results of the present study verify that children in an agricultural region of China were widely exposed to carbamate pesticides. Carbamate exposure in utero and at three and seven years may adversely impact children's neurodevelopment.
发育期早期的氨基甲酸酯暴露与不良健康影响有关，引起了人们的关注。
本研究纳入了 303 名 7 岁儿童。使用气相色谱-串联质谱法测定尿中克百威酚浓度。采用韦氏儿童智力量表中国修订版评估言语、操作和全量表智商（IQ、IQ 和 IQ）。使用广义线性模型探讨克百威酚水平与智商之间的关系。使用广义估计方程探讨长期健康效应和敏感时间窗。
96.6%的 7 岁儿童尿液样本中检测到克百威酚，克百威酚浓度的几何平均值、中位数和四分位距分别为 0.67μg/L、0.30μg/L 和 0.09-3.72μg/L，与 SMBCS 队列中 3 岁儿童的水平相似。7 岁时的克百威酚水平与智商呈负相关[β=-0.044；95%置信区间（CI）：-0.087，-0.001；p=0.045]。3 岁时的克百威酚水平与智商（β=-0.100；95%CI：-0.186，-0.014；p=0.022）和智商（β=-0.087；95%CI：-0.173，-0.001；p=0.047）呈负相关。母亲和儿童在 3 岁和 7 岁时接触氨基甲酸酯与儿童在 7 岁时的智商（β=-0.089；95%CI：-0.171，-0.007；p=0.034）和智商（β=-0.064；95%CI：-0.127，-0.000；p=0.049）呈负相关。
本研究结果证实，中国一个农业地区的儿童广泛接触氨基甲酸酯类农药。宫内和 3 岁及 7 岁时接触氨基甲酸酯可能对儿童的神经发育产生不利影响。
